Centre for Genomics and Child Health: Recent submissions
Now showing items 281-300 of 835
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Tobacco control and the ERS: new problems and old foes
(European Respiratory Society, 2021-01-05) -
The Genomic Loci of Specific Human tRNA Genes Exhibit Ageing-Related DNA Hypermethylation
The epigenome has been shown to deteriorate with age, potentially impacting on ageing-related disease. tRNA, while arising from only ~46kb (<0.002% genome), is the second most abundant cellular transcript. tRNAs also control ... -
High-throughput STELA provides a rapid test for the diagnosis of telomere biology disorders.
(Springer Nature, 2021-03-11)Telomere biology disorders are complex clinical conditions that arise due to mutations in genes required for telomere maintenance. Telomere length has been utilised as part of the diagnostic work-up of patients with these ... -
Genomewide Association Study of Severe Covid-19 with Respiratory Failure.
(2020-10-15)BACKGROUND: There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (Covid-19). Genomewide ... -
Vitamin D3 and B12 Supplementation in Pregnancy.
(Elsevier, 2021-03-01)AIM: To assess the efficacy of vitamin D3 or B12 supplementation during pregnancy. METHODS: Pregnant women at 6-14 weeks in the intervention arm received oral high dose intermittent vitamin D3 and/or low dose B12 supplementation ... -
Genetic mechanisms of critical illness in Covid-19.
(2020-12-11)Host-mediated lung inflammation is present,1 and drives mortality,2 in critical illness caused by Covid-19. Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development.3 ... -
LINE retrotransposons characterize mammalian tissue-specific and evolutionarily dynamic regulatory regions.
(BioMed Central, 2021-02-18)BACKGROUND: To investigate the mechanisms driving regulatory evolution across tissues, we experimentally mapped promoters, enhancers, and gene expression in the liver, brain, muscle, and testis from ten diverse mammals. ... -
Health outcomes in Undernutrition: the role of nutrients, gut dysfunction and the gut microbiome (HUNGer)
(Imperial College, 2019-01-01)The HUNGer consortium is comprised of a multi-disciplinary, multi-national consortium of world-leading researchers, with expertise in physiology and nutrition, through to clinical research, public health and agriculture ... -
Maternal omega-3 fatty acids regulate offspring obesity through persistent modulation of gut microbiota.
(2018-05-24)BACKGROUND: The early-life gut microbiota plays a critical role in host metabolism in later life. However, little is known about how the fatty acid profile of the maternal diet during gestation and lactation influences the ... -
Asthma prescribing according to Arg16Gly beta-2 genotype: a randomized trial in adolescents
The A allele of rs1042713 (Arg16 amino acid) in the β2-adrenoreceptor is associated with poor response to long-acting β2-agonist (LABA) in young people with asthma. Our aim was to assess whether the prescribing of second-line ... -
First analysis of the Severe Paediatric Asthma Collaborative in Europe registry.
(2020-10)New biologics are being continually developed for paediatric asthma, but it is unclear whether there are sufficient numbers of children in Europe with severe asthma and poor control to recruit to trials needed for registration. ... -
Intestinal Inflammation is Linked to Hypoacetylation of Histone 3 Lysine 27 and can be Reversed by Valproic Acid Treatment in Inflammatory Bowel Disease Patients.
(Elsevier Inc. on behalf of the AGA Institute, 2020-11-21) -
LGG-57. SIGNALLING MECHANISMS IN PAEDIATRIC LOW-GRADE GLIOMA
(Oxford University Press on behalf of the Society for Neuro-Oncology., 2020-12-04)Abstract LGG-57 from the 19th International Symposium on Pediatric Neuro-Oncology (ISPNO 2020) -
The Gut Microbiome in Child Malnutrition.
(2020)Undernutrition affects almost 25% of all children under the age of 5 worldwide and underlies almost half of all child deaths. Child undernutrition is also associated with long-term growth deficits, in addition to reduced ... -
Omega-3 polyunsaturated fatty acids critically regulate behaviour and gut microbiota development in adolescence and adulthood.
(2017-01)BACKGROUND: Neurodevelopment is strongly influenced by maternal and early-postnatal diet. Omega-3 polyunsaturated fatty acids (n-3 PUFA) are vital structural and functional components of the developing brain. The gut ... -
Advanced glycation end products and wheeze: A plausible association?
(BMJ, 2021-01-01) -
Deficiency of essential dietary n-3 PUFA disrupts the caecal microbiome and metabolome in mice.
(2017-12)n-3 PUFA are lipids that play crucial roles in immune-regulation, cardio-protection and neurodevelopment. However, little is known about the role that these essential dietary fats play in modulating caecal microbiota ...