Centre for Genomics and Child Health: Recent submissions
Now showing items 261-280 of 835
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Severe obesity and diabetes insipidus in a patient with PCSK1 deficiency
(Elsevier, 2013) -
Associations between maternal obesity and infectious morbidity in Zimbabwean infants
(2021-04-28)The prevalence of overweight and obesity is increasing among reproductive-age women in sub-Saharan Africa. Whether maternal body mass index (BMI) influences the risk of infant infections in low- and middle-income countries ... -
Maternal fecal microbiome predicts gestational age, birth weight and neonatal growth in rural Zimbabwe.
(2021-06-14)BACKGROUND: Preterm birth and low birth weight (LBW) affect one in ten and one in seven livebirths, respectively, primarily in low-income and middle-income countries (LMIC) and are major predictors of poor child health ... -
Multi-omics phenotyping of the gut-liver axis reveals metabolic perturbations from a low-dose pesticide mixture in rats.
(Springer Nature, 2021-04-14)Health effects of pesticides are not always accurately detected using the current battery of regulatory toxicity tests. We compared standard histopathology and serum biochemistry measures and multi-omics analyses in a ... -
Effect of controller prescribing according to rs1042713 genotype on asthma related quality of life in young people (PACT): a randomized controlled trial
(European Respiratory Society, 2020-09-07) -
Oxidative stress, short-term exposure to air pollution, and lung function in children
(European Respiratory Society, 2017-12-06)Background: Although the mechanism underlying air pollution exposure’s adverse effects on lung function is unclear, oxidative stress is implicated in a range of adverse health effects of air pollution. Urinary 8-Oxo-2'-d ... -
Talking to patients and families about air pollution
(Elsevier Ltd., 2020-07-11)Air pollution's health effects are extensive and varied, but are particularly prevalent in the respiratory system. With this comes media interest and public interest, not only in the effects of air pollution but also how ... -
Chronic constipation in the elderly: an unusual presentation of colonic dysmotility in an elderly patient.
(Hindawi Publishing Corporation, 2013)Introduction. Chronic constipation is common in the elderly, and often no underlying pathology is found. Primary colonic dysmotility has been described in children but is rare in the elderly. Case report. We present an ... -
Evaluating the utility of urinary metal concentrations as biomarkers of air pollutant exposures
(2017-09-01)Abstract from ERS International Congress 2017 -
Next-generation sequencing for the diagnosis of hepatitis B: current status and future prospects.
(2021-04-21)INTRODUCTION: Hepatitis B virus (HBV) causes a complex and persistent infection with a major impact on patients health. Viral-genome sequencing can provide valuable information for characterizing virus genotype, infection ... -
The management of adult patients with severe chronic small intestinal dysmotility
(BMJ, 2020-08-21)Adult patients with severe chronic small intestinal dysmotility are not uncommon and can be difficult to manage. This guideline gives an outline of how to make the diagnosis. It discusses factors which contribute to ... -
Air pollution and children's health: Where next?
(2021-04-13) -
Biomarkers of environmental enteric dysfunction are not consistently associated with linear growth velocity in rural Zimbabwean infants.
(2021-03-19)BACKGROUND: Child stunting remains a poorly understood, prevalent public health problem. Environmental enteric dysfunction (EED) is hypothesized to be an important underlying cause. OBJECTIVES: Within a subgroup of 1169 ... -
The United Kingdom's global health funding cuts will exacerbate inequities.
(2021-04-12)To the Editor -
Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation.
(Nature Research (part of Springer Nature), 2021-04-12)Deregulation of chromatin modifiers plays an essential role in the pathogenesis of medulloblastoma, the most common paediatric malignant brain tumour. Here, we identify a BMI1-dependent sensitivity to deregulation of ... -
Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma.
(Oxford University Press, 2021-03-22)Glioblastoma (GBM) is the most common and aggressive intrinsic brain tumour in adults. Epigenetic mechanisms controlling normal brain development are often dysregulated in GBM. Among these, BMI1, a structural component of ... -
An enhanced care package to improve asthma management in Malawian children: a randomised controlled trial.
(BMJ, 2021-01-21)BACKGROUND: Shortages of clinical staff make chronic asthma care challenging in low-income countries. We evaluated an outpatient asthma care package for children, including task-shifting of asthma management roles. METHODS: ...