Centre for Genomics and Child Health: Recent submissions
Now showing items 241-260 of 835
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Emerging Roles of Repetitive and Repeat-Containing RNA in Nuclear and Chromatin Organization and Gene Expression
(Frontiers Media, 2021-10-06)Genomic repeats have been intensely studied as regulatory elements controlling gene transcription, splicing and genome architecture. Our understanding of the role of the repetitive RNA such as the RNA coming from genomic ... -
Long Non-Coding RNA (lncRNA) Roles in Cell Biology, Neurodevelopment and Neurological Disorders.
(MDPI, 2021-06-17)Development is a complex process regulated both by genetic and epigenetic and environmental clues. Recently, long non-coding RNAs (lncRNAs) have emerged as key regulators of gene expression in several tissues including the ... -
Regional differences in short stature in England between 2006 and 2019: A cross-sectional analysis from the National Child Measurement Programme.
(Public Library of Science, 2021-09-28)BACKGROUND: Short stature, defined as height for age more than 2 standard deviations (SDs) below the population median, is an important indicator of child health. Short stature (often termed stunting) has been widely ... -
Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC‐derived neural stem cells in glioblastoma.
(Nature Research (part of Springer Nature), 2021-10-21) -
Expression of p16 Within Myenteric Neurons of the Aged Colon: A Potential Marker of Declining Function.
(2021)Human colonic neuromuscular functions decline among the elderly. The aim was to explore the involvement of senescence. A preliminary PCR study looked for age-dependent differences in expression of CDKN1A (encoding the ... -
Genome wide whole blood transcriptome profiling across inherited bone marrow failure subtypes.
(2021-10-08)Gene expression profiling has long been used in understanding the contribution of genes and related pathways in disease pathogenesis and susceptibility. We have performed whole blood transcriptomic profiling in a subset ... -
The presence of air pollution particulate matter in cryopreserved placental tissue cells.
(2021-07)Carbonaceous particles seen in frozen human macrophage-enriched placental cells can be used as a biomarker of personal exposure to combustion-derived particulate matter. The feasibility of using frozen tissues will allow ... -
Childhood asthma outcomes during the COVID-19 pandemic: Findings from the PeARL multi-national cohort.
(2021-06)BACKGROUND: The interplay between COVID-19 pandemic and asthma in children is still unclear. We evaluated the impact of COVID-19 pandemic on childhood asthma outcomes. METHODS: The PeARL multinational cohort included 1,054 ... -
Transcriptomics of the Prader-Willi syndrome hypothalamus.
(2021)Prader-Willi syndrome (PWS) is a complex neurodevelopmental disorder, arising from a loss of paternity expressed genetic material on the imprinted chromosome locus 15q11-q13. Despite increasing clarity on the underlying ... -
INOSITOL TREATMENT INHIBITS MEDULLOBLASTOMA THROUGH SUPPRESSION OF EPIGENETIC-DRIVEN METABOLIC ADAPTATION
(2021-06)Abstract EMBR-10 -
Optogenetic modeling of human neuromuscular circuits in Duchenne muscular dystrophy with CRISPR and pharmacological corrections.
(American Association for the Advancement of Science, 2021-09-10)Duchenne muscular dystrophy (DMD) is caused by dystrophin gene mutations leading to skeletal muscle weakness and wasting. Dystrophin is enriched at the neuromuscular junction (NMJ), but how NMJ abnormalities contribute to ...