Centre for Immunobiology: Recent submissions
Now showing items 521-540 of 1121
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KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity
(2019-02-28)ABSTRACT CpG islands (CGI) are associated with the majority of mammalian gene promoters and function to recruit chromatin modifying enzymes. It has therefore been proposed that CGIs regulate gene expression through ... -
SOLUBLE GUANYLATE CYCLASE ACTIVATORS AS COMBINATION ANTI-PLATELET THERAPY WITH P2Y12 INHIBITORS AND PDE INHIBITORS: IN VIVO AND EX VIVO STUDIES
(BMJ Publishing Group Ltd, 2016-06-03)Methods Mice were pre-treated with vehicle, prasugrel (0.3 mg/kg), cinaciguat (0.3 mg/kg) + dipyridamole (2.0 mg/kg), or prasugrel + cinaciguat + dipyridamole (triple) and anesthetized. To measure in vivo thrombus formation, ... -
Skin barrier immunity and ageing
(Wiley Online, 2019-12-04)The skin is the outermost layer of the body with an extensive surface area of approximately 1·8 m2 , and is the first line of defence against a multitude of external pathogens and environmental insults. The skin also has ... -
Multiyear Follow-up of AAV5-hFVIII-SQ Gene Therapy for Hemophilia A.
(Massachusetts Medical Society, 2020-01-02)BACKGROUND: Adeno-associated virus (AAV)-mediated gene therapy is under investigation as a therapeutic option for persons with hemophilia A. Efficacy and safety data include 3 years of follow-up after a single administration ... -
Long-Acting Cabotegravir and Rilpivirine after Oral Induction for HIV-1 Infection.
(Massachusetts Medical Society, 2020-03-19)BACKGROUND: Long-acting injectable regimens may simplify therapy for patients with human immunodeficiency virus type 1 (HIV-1) infection. METHODS: We conducted a phase 3, randomized, open-label trial in which adults with ... -
The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery.
(Elsevier, 2016-11-17)The International Human Epigenome Consortium (IHEC) coordinates the generation of a catalog of high-resolution reference epigenomes of major primary human cell types. The studies now presented (see the Cell Press IHEC web ... -
ICAM-1 contributes to the preferential binding of platelets to classical and intermediate monocyte subsets over neutrophils
(Wiley Online, 2019-07-09)Platelet‐leukocyte interactions have beenlinked to a range of cardiovascular and inflammatory disease states.A variety of mechanisms have been proposed to facilitate platelet–neutrophil and platelet–monocyte interactions, ... -
Impact of Zostavax Vaccination on T-Cell Accumulation and Cutaneous Gene Expression in the Skin of Older Humans After Varicella Zoster Virus Antigen-Specific Challenge
(Oxford University Press, 2018-09-22)Background The live attenuated vaccine Zostavax was developed to prevent varicella zoster virus (VZV) reactivation that causes herpes zoster (shingles) in older humans. However, the impact of vaccination on the cutaneous ... -
Prevalence of Clostridium difficile and its toxins in hospital patients with diarrhoeal diseases in Lusaka, Zambia.
(Oxford University Press, 2019-10-04)BACKGROUND: Clostridium difficile infection (CDI) has emerged as an important nosocomial and antibiotic-associated diarrhoeal problem leading to increasing morbidity and mortality, especially in resource-privileged regions. ... -
Recombinant factor VIII products and inhibitor development in previously untreated patients with severe haemophilia A: Combined analysis of three studies.
(Wiley Online, 2019-05-07)INTRODUCTION: Standard treatment of congenital haemophilia A is based on replacement therapy with coagulation factor VIII (FVIII) products. A major complication of FVIII therapy is the occurrence of IgG alloantibodies ... -
Safety and efficacy of emicizumab and other novel agents in newborns and infants.
(Wiley Online, 2019-07-30)The evolution of a non‐clotting factor category of therapeutic agents, including diverse strategies of manipulating the positive and negative regulators of haemostasis, presents a paradigm shift in de‐creasing the ... -
Mycobacterium tuberculosis bloodstream infection prevalence, diagnosis, and mortality risk in seriously ill adults with HIV: a systematic review and meta-analysis of individual patient data.
(Elsevier, 2020-03-13)BACKGROUND: The clinical and epidemiological significance of HIV-associated Mycobacterium tuberculosis bloodstream infection (BSI) is incompletely understood. We hypothesised that M tuberculosis BSI prevalence has been ...