Centre for Immunobiology: Recent submissions
Now showing items 501-520 of 1121
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Circulating Senescent T Cells Are Linked to Systemic Inflammation and Lesion Size During Human Cutaneous Leishmaniasis
(Frontiers Media, 2019-01-04)Leishmania (Viannia) braziliensis induces American tegumentary leishmaniasis that ranges in severity from the milder form, cutaneous (CL) to severe disseminated cutaneous leishmaniasis. Patients with CL develop a ... -
Platelet Reactivity in Individuals Over 65 Years Old Is not Modulated by Age.
(On behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc., 2020-04-27) -
Slicing and dicing viruses: antiviral RNA interference in mammals
(EMBO, 2019-04-15)To protect against the harmful consequences of viral infections, organisms are equipped with sophisticated antiviral mechanisms, including cell‐intrinsic means to restrict viral replication and propagation. Plant and ... -
Combination of cyclic nucleotide modulators with P2Y12 receptor antagonists as anti-platelet therapy
(Wiley, 2020-04-11)BACKGROUND: Endothelium-derived prostacyclin and nitric oxide elevate platelet cyclic nucleotide levels and maintain quiescence. We previously demonstrated that a synergistic relationship exists between cyclic nucleotides ... -
Senescent cells evade immune clearance via HLA-E-mediated NK and CD8(+) T cell inhibition
(Springer Nature, 2019-06-03)Senescent cells accumulate in human tissues during ageing and contribute to age-related pathologies. The mechanisms responsible for their accumulation are unclear. Here we show that senescent dermal fibroblasts express ... -
The RIG‐I‐like receptor LGP2 inhibits Dicer‐dependent processing of long double‐stranded RNA and blocks RNA interference in mammalian cells
(EMBO, 2018-02-15)In vertebrates, the presence of viral RNA in the cytosol is sensed by members of the RIG ‐I‐like receptor (RLR ) family, which signal to induce production of type I interferons (IFN ). These key antiviral cytokines act in ... -
Recent advances in gut immunology
(2017) -
Oral Anti-Tumour Necrosis Factor Domain Antibody V565 Provides High Intestinal Concentrations, and Reduces Markers of Inflammation in Ulcerative Colitis Patients.
(2019-10-01)V565 is an engineered TNFα-neutralising single domain antibody formulated into enteric coated mini-tablets to enable release in the intestine after oral administration as a possible oral treatment for inflammatory bowel ... -
Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2.
(Springer Nature, 2020-03-20)Proteolysis-Targeting Chimeras (PROTACs) are heterobifunctional small-molecules that can promote the rapid and selective proteasome-mediated degradation of intracellular proteins through the recruitment of E3 ligase complexes ... -
Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases.
(2019-07-02)RIP2 kinase has been identified as a key signal transduction partner in the NOD2 pathway contributing to a variety of human pathologies, including immune-mediated inflammatory diseases. Small-molecule inhibitors of RIP2 ... -
Homeostasis of the gut barrier and potential biomarkers
(American Physiological Society, 2017-03-01)The gut barrier plays a crucial role by spatially compartmentalizing bacteria to the lumen through the production of secreted mucus and is fortified by the production of secretory IgA (sIgA) and antimicrobial peptides and ...