Centre for Immunobiology: Recent submissions
Now showing items 441-460 of 1121
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Cancer cells, on your histone marks, get SETDB1, silence retrotransposons, and go!
(2017-11-06)Cancer cells thrive on genetic and epigenetic changes that confer a selective advantage but also need strategies to avoid immune recognition. In this issue, Cuellar et al. (2017. J. Cell Biol https://doi.org/10.1083/jcb.201612160) ... -
MDR/XDR-TB management of patients and contacts: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network.
(Elsevier, 2020-03)The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health ... -
Epigenetic control of retrotransposons in adult tissues: implications for immune regulation.
(2017-08)Retrotransposons tune immune reactivity in differentiated cells because when they are transcribed, their nucleic acids can be viewed as non-self leading to innate immune sensing. Most retrotransposons, however, are subject ... -
STAT2 IS A KEY MEDIATOR OF ACUTE PANCREATITIS
(2017-07) -
Non-invasive markers of liver fibrosis in fatty liver disease are unreliable in people of South Asian descent.
(2018-04)Objective: Liver biopsy is the most accurate method for determining stage and grade of injury in non-alcoholic fatty liver disease (NAFLD). Given risks and limitations of biopsy, non-invasive tests such as NAFLD fibrosis ... -
Identification of a homozygous recessive variant in PTGS1 resulting in a congenital aspirin-like defect in platelet function.
(2020-04-16)We have identified a rare missense variant on chromosome 9, position 125145990 (GRCh37), in exon 8 in PTGS1 (the gene encoding cyclo-oxygenase 1, COX-1, the target of anti-thrombotic aspirin therapy). We report that in the ...