Centre for Immunobiology: Recent submissions
Now showing items 301-320 of 1121
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Effects of Bovine Colostrum with or without Egg on In Vitro Bacterial-Induced Intestinal Damage with Relevance for SIBO and Infectious Diarrhea.
(MDPI, 2021-03-22)Small intestinal bacterial overgrowth (SIBO) occurs commonly, is difficult to treat, and frequently recurs. Bovine colostrum (BC) and chicken eggs contain immunoglobulins and other components that possess antimicrobial, ... -
The contribution of environmental enteropathy to the global problem of micronutrient deficiency.
(Cambridge University Press, 2021-03-05)Sometimes referred to as hidden hunger, micronutrient deficiencies persist on a global scale. For some micronutrients this appears to be due to inadequate intake, for others intake may not match increased requirements. ... -
Use-case scenarios for an anti-Cryptosporidium therapeutic.
(Public Library of Science, 2021-03-11)Cryptosporidium is a widely distributed enteric parasite that has an increasingly appreciated pathogenic role, particularly in pediatric diarrhea. While cryptosporidiosis has likely affected humanity for millennia, its ... -
Comprehensive mapping of tissue cell architecture via integrated single cell and spatial transcriptomics
(Cold Spring Harbor Laboratory, 2020)The spatial organization of cell types in tissues fundamentally shapes cellular interactions and function, but the high-throughput spatial mapping of complex tissues remains a challenge. We present сell2location, a principled ... -
Diagnostic Pitfalls of Urogenital Tuberculosis.
(2021-04-04)OBJECTIVES: To describe characteristics, details of diagnosis and outcomes of urogenital tuberculosis (UGTB) in a low prevalence country. METHODS: We conducted a retrospective observational study of 37 consecutive patients ... -
Screening for tuberculosis among high-risk groups attending London Emergency Departments: A prospective observational study.
(European Respiratory Society, 2021-03-18) -
Outcome of treatment of MDR-TB or drug-resistant patients treated with bedaquiline and delamanid: Results from a large global cohort.
(2021-03-19)The World Health Organization (WHO) recommends countries introduce new anti-TB drugs in the treatment of multidrug-resistant tuberculosis. The aim of the study is to prospectively evaluate the effectiveness of bedaquiline ... -
Integrated single-cell transcriptomics and epigenomics reveals strong germinal center-associated etiology of autoimmune risk loci
(2021-03-17)This article is a preprint and has not been certified by peer review. The germinal center (GC) response is critical for both effective adaptive immunity and establishing peripheral tolerance by limiting auto-reactive B ... -
Cyclooxygenases and the cardiovascular system
(2021-01) -
TB management in the European Union/European Economic Area: a multi‐centre survey
(International Union Against Tuberculosis and Lung Disease, 2021-02-01) -
Antibody repertoire and gene expression dynamics of diverse human B cell states during affinity maturation
(2020-04-30)Pre-print (not been peer-reviewed). Now published in Science Immunology doi: 10.1126/sciimmunol.abe6291 . Abstract: In response to antigen challenge, B cells clonally expand, undergo selection and differentiate to ... -
Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics.
(2021-02-12)Protective humoral memory forms in secondary lymphoid organs where B cells undergo affinity maturation and differentiation into memory or plasma cells. Here, we provide a comprehensive roadmap of human B cell maturation ... -
Switching from boosted PIs to dolutegravir in HIV-infected patients with high cardiovascular risk: 48 week effects on subclinical cardiovascular disease.
(2020-11-01)BACKGROUND: Switching from boosted PIs to dolutegravir in virologically suppressed HIV-infected patients with high cardiovascular risk significantly decreased total cholesterol and other proatherogenic lipid fractions at ... -
Safety and Efficacy of Ombitasvir, Paritaprevir With Ritonavir ± Dasabuvir With or Without Ribavirin in Patients With Human Immunodeficiency Virus-1 and Hepatitis C Virus Genotype 1 or Genotype 4 Coinfection: TURQUOISE-I Part 2.
(2017)BACKGROUND: Ombitasvir, paritaprevir with ritonavir, and dasabuvir (OBV/PTV/r ± DSV) ±ribavirin (RBV) are approved to treat hepatitis C virus (HCV) genotype 1 and 4 infection. Here, we investigate the safety and efficacy ... -
A Double-Blind, Placebo-Controlled Trial to Assess Safety and Tolerability of (Thetanix) Bacteroides thetaiotaomicron in Adolescent Crohn's Disease.
(2020-12-18)INTRODUCTION: Thetanix (gastroresistant capsules containing lyophilized Bacteroides thetaiotaomicron) is a live biotherapeutic, under development for Crohn's disease, that antagonizes transcription factor nuclear factor ...