Browsing Centre for Immunobiology by Subject "Humans"
Now showing items 1-20 of 90
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AAV5-Factor VIII Gene Transfer in Severe Hemophilia A.
(2017-12-28)BACKGROUND: Patients with hemophilia A rely on exogenous factor VIII to prevent bleeding in joints, soft tissue, and the central nervous system. Although successful gene transfer has been reported in patients with hemophilia ... -
The African Esophageal Cancer Consortium: A Call to Action.
(2018-09)Esophageal cancer is the eighth most common cancer worldwide and the sixth most common cause of cancer-related death; however, worldwide incidence and mortality rates do not reflect the geographic variations in the occurrence ... -
Anti-interleukin-21 antibody and liraglutide for the preservation of β-cell function in adults with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled, phase 2 trial.
(2021-04)BACKGROUND: Type 1 diabetes is characterised by progressive loss of functional β-cell mass, necessitating insulin treatment. We aimed to investigate the hypothesis that combining anti-interleukin (IL)-21 antibody (for ... -
Antibiotic use and resistance in children with severe acute malnutrition and human immunodeficiency virus infection.
(2023-01)Severe acute malnutrition (SAM) and human immunodeficiency virus (HIV) infection underlie a major proportion of the childhood disease burden in low- and middle-income countries. These diseases commonly co-occur and lead ... -
Antisense Oligonucleotide Induction of the hnRNPA1b Isoform Affects Pre-mRNA Splicing of SMN2 in SMA Type I Fibroblasts.
(2022-04-01)Spinal muscular atrophy (SMA) is a severe, debilitating neuromuscular condition characterised by loss of motor neurons and progressive muscle wasting. SMA is caused by a loss of expression of SMN1 that encodes the survival ... -
Assessment of Platelet Function by High-Throughput Screening Light Transmission Aggregometry: Optimul Assay.
(2023)Platelet function testing is critical in the diagnosis of bleeding disorders and allows monitoring of antiplatelet therapy. The gold standard assay, light transmission aggregometry (LTA), was developed 60 years ago and ... -
Bacterial community development in experimental gingivitis.
(2013)Current knowledge of the microbial composition of dental plaque in early gingivitis is based largely on microscopy and cultural methods, which do not provide a comprehensive description of oral microbial communities. This ... -
Barriers and enablers to the effective implementation of omics research in low- and middle-income countries.
(Nature Research, 2024-06-17) -
Brief Report: Long-Term (96-Week) Efficacy and Safety After Switching From Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide in HIV-Infected, Virologically Suppressed Adults.
(2017-06-01)In a double-blind, phase 3 trial, 663 HIV-infected, virologically suppressed adults were randomized to switch to tenofovir alafenamide (TAF; n = 333) vs. remain on tenofovir disoproxil fumarate (TDF; n = 330), each ... -
Cancer cells, on your histone marks, get SETDB1, silence retrotransposons, and go!
(2017-11-06)Cancer cells thrive on genetic and epigenetic changes that confer a selective advantage but also need strategies to avoid immune recognition. In this issue, Cuellar et al. (2017. J. Cell Biol https://doi.org/10.1083/jcb.201612160) ... -
Chronic rhinosinusitis with nasal polyps: eosinophils versus B lymphocytes in disease pathogenesis.
(2024-02-01)PURPOSE OF REVIEW: To highlight the current evidence that supports the view that eosinophils may not drive disease in chronic rhinosinusitis with nasal polyps (CRSwNP) and the emerging evidence for B cells as an important ... -
Classifying necrotising mpox as an AIDS-defining condition.
(2023-11-11) -
Clinical picture and treatment of 2212 patients with common variable immunodeficiency.
(Elsevier, 2014-02-28)BACKGROUND: Common variable immunodeficiency (CVID) is an antibody deficiency with an equal sex distribution and a high variability in clinical presentation. The main features include respiratory tract infections and their ... -
Country-specific lockdown measures in response to the COVID-19 pandemic and its impact on tuberculosis control: a global study.
(2022)The objective of this study was to describe country-specific lockdown measures and tuberculosis indicators collected during the first year of the COVID-19 pandemic. Data on lockdown/social restrictions (compulsory face ... -
Diabetes: Concepts of β-Cell Organ Dysfunction and Failure Would Lead to Earlier Diagnoses and Prevention.
(2021-11)As the world endures a viral pandemic superimposed on a diabetes pandemic, the latter incorporates most of the comorbidities associated with the former, thereby exacerbating risk of death in both. An essential approach to ... -
Diagnostic yield of nontuberculous mycobacteria in patients booked for endoscopy at the University Teaching Hospital, Lusaka.
(2017-01-07)BACKGROUND: The intestinal carriage of nontuberculous mycobacteria (NTM) is associated with disease, especially in severely immunocompromised individuals. These organisms, although often considered contaminants, have been ... -
Differential regulation of nuclear and mitochondrial Bcl-2 in T cell apoptosis.
(2008-01)Activated T cells require anti-apoptotic cytokines for their survival. The anti-apoptotic effects of these factors are mediated by their influence on the balance of expression and localisation of pro- and anti-apoptotic ... -
Dynamic control of endogenous retroviruses during development.
(2011-03-15)Close to half of the human genome encompasses mobile genetic elements, most of which are retrotransposons. These genetic invaders are formidable evolutionary forces that have shaped the architecture of the genomes of higher ...