Methods for monitoring and measurement of protein translation in time and space
Pagination
2477 - 2488
Publisher
DOI
10.1039/c7mb00476a
Journal
Molecular BioSystems
ISSN
1742-206X
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Show full item recordAbstract
Regulation of protein translation constitutes a crucial step in control of gene expression. In comparison
to transcriptional regulation, however, translational control has remained a significantly under-studied
layer of gene expression. This trend is now beginning to shift thanks to recent advances in nextgeneration sequencing, proteomics, and microscopy based methodologies which allow accurate
monitoring of protein translation rates, from single target messenger RNA molecules to genome-wide
scale studies. In this review, we summarize these recent advances, and discuss how they are enabling
researchers to study translational regulation in a wide variety of in vitro and in vivo biological systems,
with unprecedented depth and spatiotemporal resolution.
Authors
Dermit, M; Dodel, M; Mardakheh, FKURI
https://pubs.rsc.org/en/content/articlepdf/2017/mb/c7mb00476ahttps://qmro.qmul.ac.uk/xmlui/handle/123456789/54832
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