dc.contributor.author | Dermit, M | |
dc.contributor.author | Dodel, M | |
dc.contributor.author | Mardakheh, FK | |
dc.date.accessioned | 2019-01-22T11:27:08Z | |
dc.date.available | 2019-01-22T11:27:08Z | |
dc.date.issued | 2017-10-12 | |
dc.identifier.citation | Dermit, M., Dodel, M. and Mardakheh, F.K. 2018. Methods for monitoring and measurement of protein translation in time and space. Mol. BioSyst., 2017,13, 2477-2488 | en_US |
dc.identifier.issn | 1742-206X | |
dc.identifier.uri | https://pubs.rsc.org/en/content/articlepdf/2017/mb/c7mb00476a | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/54832 | |
dc.description.abstract | Regulation of protein translation constitutes a crucial step in control of gene expression. In comparison
to transcriptional regulation, however, translational control has remained a significantly under-studied
layer of gene expression. This trend is now beginning to shift thanks to recent advances in nextgeneration sequencing, proteomics, and microscopy based methodologies which allow accurate
monitoring of protein translation rates, from single target messenger RNA molecules to genome-wide
scale studies. In this review, we summarize these recent advances, and discuss how they are enabling
researchers to study translational regulation in a wide variety of in vitro and in vivo biological systems,
with unprecedented depth and spatiotemporal resolution. | en_US |
dc.description.sponsorship | The authors are funded by a Medical Research Council (MRC) Career Development Award to F. K. M. (MR/P009417/1). | en_US |
dc.format.extent | 2477 - 2488 | |
dc.language.iso | en | en_US |
dc.publisher | Royal Society of Chemistry | en_US |
dc.relation.ispartof | Molecular BioSystems | |
dc.rights | Creative Commons Attribution License | |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.title | Methods for monitoring and measurement of protein translation in time and space | en_US |
dc.type | Article | en_US |
dc.rights.holder | Royal Society of Chemistry 2017 | |
dc.identifier.doi | 10.1039/c7mb00476a | |
dcterms.dateAccepted | 2017-10-12 | |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |