dc.contributor.author | Curry, NS | en_US |
dc.contributor.author | Davenport, R | en_US |
dc.date.accessioned | 2019-01-17T13:41:13Z | |
dc.date.available | 2018-12-13 | en_US |
dc.date.issued | 2019-02 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/54746 | |
dc.description | This is the peer reviewed version of the following article: Curry, N. S. and Davenport, R. (2018), Transfusion strategies for major haemorrhage in trauma. Br J Haematol. doi:10.1111/bjh.15737, which has been published in final form at https://doi.org/10.1111/bjh.15737. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | en_US |
dc.description.abstract | Trauma is a leading cause of death worldwide in persons under 44 years of age, and uncontrolled haemorrhage is the most common preventable cause of death in this patient group. The transfusion management of trauma haemorrhage is unrecognisable from 20 years ago. Changes in clinical practice have been driven primarily by an increased understanding of the pathophysiology of trauma-induced coagulopathy (TIC), which is associated with poor clinical outcomes, including a 3- to 4-fold increased risk of death. Targeting this coagulopathy alongside changes to surgical and anaesthetic practices (an overarching strategy known as damage control surgery/damage control resuscitation) has led to a significant reduction in mortality rates over the last two decades. This narrative review will discuss the transfusion practices that are currently used for trauma haemorrhage and the evidence that supports these practices. | en_US |
dc.format.extent | 508 - 523 | en_US |
dc.language | eng | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Br J Haematol | en_US |
dc.subject | major bleeding | en_US |
dc.subject | transfusion | en_US |
dc.subject | trauma | en_US |
dc.subject | trauma induced coagulopathy | en_US |
dc.subject | Blood Coagulation Disorders | en_US |
dc.subject | Blood Transfusion | en_US |
dc.subject | Hemorrhage | en_US |
dc.subject | Humans | en_US |
dc.subject | Resuscitation | en_US |
dc.subject | Risk Factors | en_US |
dc.subject | Wounds and Injuries | en_US |
dc.title | Transfusion strategies for major haemorrhage in trauma. | en_US |
dc.type | Article | |
dc.rights.holder | 2018 British Society for Haematology and John Wiley & Sons Ltd | |
dc.identifier.doi | 10.1111/bjh.15737 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/30592036 | en_US |
pubs.issue | 4 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 184 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |