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    Neurofilament light as an immune target for pathogenic antibodies. 
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    Neurofilament light as an immune target for pathogenic antibodies.

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    Published version
    Embargoed until: 5555-01-01
    Volume
    152
    Pagination
    580 - 588
    DOI
    10.1111/imm.12797
    Journal
    Immunology
    Issue
    4
    Metadata
    Show full item record
    Abstract
    Antibodies to neuronal antigens are associated with many neurological diseases including paraneoplastic neurological disorders, epilepsy, amyotrophic lateral sclerosis and multiple sclerosis. Immunization with neuronal antigens such as neurofilament light (NF-L), a neuronal intermediate filament in axons, has been shown to induce neurological disease and spasticity in mice. Also, although antibodies to NF-L are widely used as surrogate biomarkers of axonal injury in amyotrophic lateral sclerosis and multiple sclerosis, it remains to be elucidated if antibodies to NF-L contribute to neurodegeneration and neurological disease. To address this, we examined the pathogenic role of antibodies directed to NF-L in vitro using spinal cord co-cultures and in vivo in experimental autoimmune encephalomyelitis (EAE) and optic neuritis animal models of multiple sclerosis. Here we show that peripheral injections of antibodies to NF-L augmented clinical signs of neurological disease in acute EAE, increased retinal ganglion cell loss in experimental optic neuritis and induced neurological signs following intracerebral injection into control mice. The pathogenicity of antibodies to NF-L was also observed in spinal cord co-cultures where axonal loss was induced. Taken together, our results reveal that as well as acting as reliable biomarkers of neuronal damage, antibodies to NF-L exacerbate neurological disease, suggesting that antibodies to NF-L generated during disease may also be pathogenic and play a role in the progression of neurodegeneration.
    Authors
    Puentes, F; van der Star, BJ; Boomkamp, SD; Kipp, M; Boon, L; Bosca, I; Raffel, J; Gnanapavan, S; van der Valk, P; Stephenson, J
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/36726
    Collections
    • Centre for Neuroscience, Surgery and Trauma [1230]
    Language
    eng
    Copyright statements
    © 2017 John Wiley & Sons Ltd
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