Browsing Centre for Tumour Biology by Subject "Cancer"
Now showing items 1-15 of 15
-
Abstract 4576: 3D in vitro models uncover malignant cell intrinsic and extrinsic mechanisms of CAR-T cell resistance in high grade serous ovarian cancer
(American Association for Cancer Research (AACR), 2023-04-04) -
Abstract 5591: Circulating tumor DNA for recurrence prediction and efficacy analysis in the ICONIC trial of peri-operative FLOT and avelumab (PD-L1) in localized esophago-gastric adenocarcinoma
(American Association for Cancer Research (AACR), 2023-04-04) -
Abstract 5593: Clonal mutation burden and evolutionary dynamics analysis in metastatic gastro-esophageal adenocarcinoma (GEA) by error corrected whole-exome circulating tumor DNA sequencing
(American Association for Cancer Research (AACR), 2023-04-04) -
Abstract 958: Effective targeting of pancreatic ductal adenocarcinoma metastases with an integrin αvβ6-targeting peptide-drug conjugate
(American Association for Cancer Research (AACR), 2021-07-01) -
Abstract P6-10-05: Mutations in the RNA Splicing Factor SF3B1 drive endocrine therapy resistance and confer a targetable replication stress response defect through PARP inhibition
(American Association for Cancer Research (AACR), 2023-03-01) -
Building invitro 3D human multicellular models of high-grade serous ovarian cancer.
(2022-03-18)Three-dimensional (3D), multicellular invitro models provide a useful platform for studying human cancer biology, particularly through deconvolution of the tumor microenvironment, or where animal models do not recapitulate ... -
The ITGB6 gene: its role in experimental and clinical biology.
(2020-12)Integrin αvβ6 is a membrane-spanning heterodimeric glycoprotein involved in wound healing and the pathogenesis of diseases including fibrosis and cancer. Therefore, it is of great clinical interest for us to understand the ... -
LiquidCNA: Tracking subclonal evolution from longitudinal liquid biopsies using somatic copy number alterations.
(2021-08-20)Cell-free DNA (cfDNA) measured via liquid biopsies provides a way for minimally invasive monitoring of tumor evolutionary dynamics during therapy. Here we present liquidCNA, a method to track subclonal evolution from ... -
NeoPredPipe: high-throughput neoantigen prediction and recognition potential pipeline.
(2019-05-22)BACKGROUND: Next generation sequencing has yielded an unparalleled means of quickly determining the molecular make-up of patient tumors. In conjunction with emerging, effective immunotherapeutics for a number of cancers, ... -
Pancreatic Cancer UK Grand Challenge: Developments and challenges for effective CAR T cell therapy for pancreatic ductal adenocarcinoma.
(2020-02-15)BACKGROUND: Death from pancreatic ductal adenocarcinoma (PDAC) is rising across the world and PDAC is predicted to be the second most common cause of cancer death in the USA by 2030. Development of effective biotherapies ... -
PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer
(Elsevier/Science Direct, 2018-02-27)Development of resistance causes failure of drugs targeting receptor tyrosine kinase (RTK) networks and represents a critical challenge for precision medicine. Here, we show that PHLDA1 downregulation is critical to ... -
Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth.
(Springer Verlag, 2013-01-23)BACKGROUND: Regulation of lipid metabolism via activation of sterol regulatory element binding proteins (SREBPs) has emerged as an important function of the Akt/mTORC1 signaling axis. Although the contribution of dysregulated ...