Browsing Centre for Tumour Biology by Title
Now showing items 67-86 of 380
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Crypt fusion as a homeostatic mechanism in the human colon.
(BMJ, 2019-03-14)OBJECTIVE: The crypt population in the human intestine is dynamic: crypts can divide to produce two new daughter crypts through a process termed crypt fission, but whether this is balanced by a second process to remove ... -
Cumulative burden of inflammation predicts colorectal neoplasia risk in ulcerative colitis: a large single-centre study.
(2017-11-17)OBJECTIVE: Ulcerative colitis (UC) is a dynamic disease with its severity continuously changing over time. We hypothesised that the risk of colorectal neoplasia (CRN) in UC closely follows an actuarial accumulative ... -
Current Perspectives on the Use of off the Shelf CAR-T/NK Cells for the Treatment of Cancer
(MDPI, 2021-04)CAR T cells have revolutionised the treatment of haematological malignancies. Despite this, several obstacles still prohibit their widespread use and efficacy. One of these barriers is the use of autologous T cells as ... -
Detecting repeated cancer evolution in human tumours from multi-region sequencing data
(Nature Research, 2018-08-31)Carcinogenesis is an evolutionary process driven by the accumulation of genomic aberrations. Recurrent sequences of genomic changes, both between and within patients, reflect repeated evolution that is valuable for ... -
DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells.
(2007-12-31)In addition to their well-known function in apoptosis, caspases are also important in several nonapoptotic processes. How caspase activity is restrained and shut down under such nonapoptotic conditions remains unknown. ... -
Disrupted Resolution Mechanisms Favor Altered Phagocyte Responses in Covid-19.
(2021-07-09)Rationale: Resolution mechanisms are central in both the maintenance of homeostasis and the return to catabasis following tissue injury and/or infections. Amongst the pro-resolving mediators, the essential fatty acid-derived ...