Browsing Centre for Tumour Biology by Title
Now showing items 332-351 of 372
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Switchable CAR-T cells mediate remission in metastatic pancreatic ductal adenocarcinoma.
(2018-08-18)OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) is a disease of unmet medical need. While immunotherapy with chimeric antigen receptor T (CAR-T) cells has shown much promise in haematological malignancies, their efficacy ... -
Targeting CDH17 in Cancer: When Blocking the Ligand Beats Blocking the Receptor?
(2018-01-15)Cadherin-17 (CDH17) has been implicated as protumorigenic for many years, but mechanisms have been unclear. A Spanish team has generated antibodies to an RGD motif in CDH17 that inhibits integrin α2β1 binding to CDH17 and ... -
Targeting FGFR signalling to disrupt cellular cross-talk in pancreatic cancer
(Elsevier, 2020-12-01) -
Targeting Versican as a Potential Immunotherapeutic Strategy in the Treatment of Cancer.
(2021)A growing body of literature links events associated with the progression and severity of immunity and inflammatory disease with the composition of the tissue extracellular matrix as defined by the matrisome. One protein ... -
Towards specific inhibition of mTORC2
(2017-12)