Browsing Centre for Tumour Biology by Title
Now showing items 157-176 of 380
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The impact of the COVID-19 pandemic upon pancreatic cancer treatment (CONTACT Study): a UK national observational cohort study.
(2023-05)INTRODUCTION: CONTACT is a national multidisciplinary study assessing the impact of the COVID-19 pandemic upon diagnostic and treatment pathways among patients with pancreatic ductal adenocarcinoma (PDAC). METHODS: The ... -
Implications of Epigenetic Drift in Colorectal Neoplasia
(2019-02-01) -
In Situ Point Mutation Detection in FFPE Colorectal Cancers Using the BaseScope Assay.
(2020)In situ mutation detection (ISMD) is a powerful tool for the characterization of tumor heterogeneity at cellular resolution while preserving tissue morphology and spatial context. The BaseScope assay is a novel approach ... -
In vivo bioassay to test the pathogenicity of missense human AIP variants.
(2018-08)BACKGROUND: Heterozygous germline loss-of-function mutations in the aryl hydrocarbon receptor-interacting protein gene (AIP) predispose to childhood-onset pituitary tumours. The pathogenicity of missense variants may pose ... -
Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses
(2019-02-22)Converting carcinomas in benign oncocytomas has been suggested as a potential anti-cancerstrategy. One of the oncocytoma hallmarks is the lack of respiratory complex I (CI). Herewe use genetic ablation of this enzyme to ... -
Inherited pathogenic mitochondrial DNA mutations and gastrointestinal stem cell populations.
(2018-12)Inherited mitochondrial DNA (mtDNA) mutations cause mitochondrial disease, but mtDNA mutations also occur somatically and accumulate during ageing. Studies have shown that the mutation load of some inherited mtDNA mutations ... -
Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments.
(2016)BACKGROUND: Enhanced macromolecule biosynthesis is integral to growth and proliferation of cancer cells. Lipid biosynthesis has been predicted to be an essential process in cancer cells. However, it is unclear which enzymes ... -
Insights Into the Pathophysiology of Esophageal Adenocarcinoma.
(2018-01)Although researchers have identified genetic alterations that contribute to development of esophageal adenocarcinoma, we know little about features of patients or environmental factors that mediate progression of chronic ... -
Integrated OMICs unveil the bone-marrow microenvironment in human leukemia.
(Cell Press, 2021-05-11)The bone-marrow (BM) niche is the spatial environment composed by a network of multiple stromal components regulating adult hematopoiesis. We use multi-omics and computational tools to analyze multiple BM environmental ...