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Multicentre derivation and validation of a colitis-associated colorectal cancer risk prediction web tool.
(BMJ, 2021-05-14)
OBJECTIVE: Patients with ulcerative colitis (UC) diagnosed with low-grade dysplasia (LGD) have increased risk of developing advanced neoplasia (AN: high-grade dysplasia or colorectal cancer). We aimed to develop and validate ...
Genetic and immune landscape evolution in MMR-deficient colorectal cancer.
(2023-11-15)
Mismatch repair-deficient (MMRd) colorectal cancers (CRCs) have high mutation burdens, which make these tumours immunogenic and many respond to immune checkpoint inhibitors. The MMRd hypermutator phenotype may also promote ...