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PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer
(Elsevier/Science Direct, 2018-02-27)
Development of resistance causes failure of drugs targeting receptor tyrosine kinase (RTK) networks and represents a critical challenge for precision medicine. Here, we show that PHLDA1 downregulation is critical to ...
Hallmarks of cancer-the new testament.
(Royal Society Publishing, 2021-01-20)
Diagnosis and treatment of disease demand a sound understanding of the underlying mechanisms, determining any Achilles' heel that can be targeted in effective therapies. Throughout history, this endeavour to decipher the ...
Targeting FGFR signalling to disrupt cellular cross-talk in pancreatic cancer
(Elsevier, 2020-12-01)