Browsing Centre for Cancer & Inflammation by Issue Date

Hypoxia facilitates tumour cell detachment by reducing expression of surface adhesion molecules and adhesion to extracellular matrices without loss of cell viability.

Hasan, NM; Adams, GE; Joiner, MC; Marshall, JF; Hart, IR (1998-06)

The effects of acute hypoxia on integrin expression and adhesion to extracellular matrix proteins were investigated in two human melanoma cell lines, HMB-2 and DX3, and a human adenocarcinoma cell line, HT29. Exposure to ...

Cell cycle perturbations and apoptosis induced by isohomohalichondrin B (IHB), a natural marine compound

Bergamaschi, D; Ronzoni, S; Taverna, S; Faretta, M; De Feudis, P; Faircloth, G; Jimeno, J; Erba, E; D'Incalci, M (1999-01)

Mode of action of thiocoraline, a natural marine compound with anti-tumour activity

Erba, E; Bergamaschi, D; Ronzoni, S; Faretta, M; Taverna, S; Bonfanti, M; Catapano, CV; Faircloth, G; Jimeno, J; D'Incalci, M (1999-06)

Isolation and characterization of an IGROV-1 human ovarian cancer cell line made resistant to Ecteinascidin-743 (ET-743)

Erba, E; Bergamaschi, D; Bassano, L; Ronzoni, S; Di Liberti, G; Muradore, I; Vignati, S; Faircloth, G; Jimeno, J; D'Incalci, M (2000-05)

beta(3)A-integrin downregulates the urokinase-type plasminogen activator receptor (u-PAR) through a PEA3/ets transcriptional silencing element in the u-PAR promoter

Hapke, S; Gawaz, M; Dehne, K; Kohler, J; Marshall, JF; Graeff, H; Schmitt, M; Reuning, U; Lengyel, E (2001-03)

Lack of mutations within ST7 gene in tumour-derived cell lines and primary epithelial tumours

Brown, VL; Proby, CM; Barnes, DM; Kelsell, DP (2002-07-15)

Palladin mutation causes familial pancreatic cancer and suggests a new cancer mechanism

Pogue-Geile, KL; Chen, R; Bronner, MP; Crnogorac-Jurcevic, T; Moyes, KW; Dowen, S; Otey, CA; Crispin, DA; George, RD; Whitcomb, DC (2006-12)

Immunohistological assessment of the synovial tissue in small joints in rheumatoid arthritis: validation of a minimally invasive ultrasound-guided synovial biopsy procedure

Scire, CA; Epis, O; Codullo, V; Humby, F; Morbini, P; Manzo, A; Caporali, R; Pitzalis, C; Montecucco, C (2007)

Pancreatic Expression database: a generic model for the organization, integration and mining of complex cancer datasets

Chelala, C; Hahn, SA; Whiteman, HJ; Barry, S; Hariharan, D; Radon, TP; Lemoine, NR; Crnogorac-Jurcevic, T (2007-11-28)

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

van Haaften, G; Dalgliesh, GL; Davies, H; Chen, L; Bignell, G; Greenman, C; Edkins, S; Hardy, C; O'Meara, S; Teague, J (2009-05)

Oncolytic Viruses for Cancer Therapy: Overcoming the Obstacles

Wong, HH; Lemoine, NR; Wang, YH (2010-01)

A global insight into a cancer transcriptional space using pancreatic data: importance, findings and flaws

Gadaleta, E; Cutts, RJ; Kelly, GP; Crnogorac-Jurcevic, T; Kocher, HM; Lemoine, NR; Chelala, C (2011-10)

A rapid method for combined analysis of common and rare variants at the level of a region, gene, or pathway.

Curtis, D (2012)

Previously described methods for the combined analysis of common and rare variants have disadvantages such as requiring an arbitrary classification of variants or permutation testing to assess statistical significance. ...

The peritoneal tumour microenvironment of high-grade serous ovarian cancer

Leinster, DA; Kulbe, H; Everitt, G; Thompson, R; Perretti, M; Gavins, FNE; Cooper, D; Gould, D; Ennis, DP; Lockley, M (2012-06)

Tumour-associated inflammatory cytokines are reduced following primary platinum-based chemotherapy in plasma of high-grade serous ovarian cancer patients

Boehm, S; Ennis, D; Dowe, T; Canosa, M; McNeish, I; Lockley, M; Balkwill, F (2013-09)

Secretome and degradome profiling shows that Kallikrein-related peptidases 4, 5, 6, and 7 induce TGF beta-1 signaling in ovarian cancer cells

Shahinian, H; Loessner, D; Biniossek, ML; Kizhakkedathu, JN; Clements, JA; Magdolen, V; Schilling, O (2014-02)

Hormesis in cancer immunology Does the quantity of an immune reactant matter?

Pearce, OMT; Laeubli, H; Bui, J; Varki, A (2014-06)

PD-1/PD-L1 mediated T-cell dysfunction in CLL is not absolute and can be at least partially reversed in vivo by the immune-modulatory drug lenalidomide

McClanahan, F; Riches, JC; Miller, S; Ghazaly, E; Day, W; Capasso, M; Gribben, J (2014-10)

Targeting inflammatory cytokines in cancer

Balkwill, F (2014-11)

Stimulation of surface IgM of chronic lymphocytic leukemia cells induces an unfolded protein response dependent on BTK and SYK

Krysov, S; Steele, AJ; Coelho, V; Linley, A; Hidalgo, MS; Carter, M; Potter, KN; Kennedy, B; Duncombe, AS; Ashton-Key, M (2014-11-13)