Browsing Centre for Cancer & Inflammation by Author "Wagner, F"
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A 3D tumor microenvironment regulates cell proliferation, peritoneal growth and expression patterns.
Loessner, D; Rockstroh, A; Shokoohmand, A; Holzapfel, BM; Wagner, F; Baldwin, J; Boxberg, M; Schmalfeldt, B; Lengyel, E; Clements, JA (2019-01)Peritoneal invasion through the mesothelial cell layer is a hallmark of ovarian cancer metastasis. Using tissue engineering technologies, we recreated an ovarian tumor microenvironment replicating this aspect of disease ... -
Humanization of bone and bone marrow in an orthotopic site reveals new potential therapeutic targets in osteosarcoma.
Wagner, F; Holzapfel, BM; McGovern, JA; Shafiee, A; Baldwin, JG; Martine, LC; Lahr, CA; Wunner, FM; Friis, T; Bas, O (2018-07)BACKGROUND: Existing preclinical murine models often fail to predict effects of anti-cancer drugs. In order to minimize interspecies-differences between murine hosts and human bone tumors of in vivo xenograft platforms, ... -
Humanization of the Prostate Microenvironment Reduces Homing of PC3 Prostate Cancer Cells to Human Tissue-Engineered Bone.
McGovern, JA; Shafiee, A; Wagner, F; Lahr, CA; Landgraf, M; Meinert, C; Williams, ED; Russell, PJ; Clements, JA; Loessner, D (2018-11-13)The primary tumor microenvironment is inherently important in prostate cancer (PCa) initiation, growth and metastasis. However, most current PCa animal models are based on the injection of cancer cells into the blood ... -
Lycopene reduces ovarian tumor growth and intraperitoneal metastatic load
Holzapfel, NP; Shokoohmand, A; Wagner, F; Landgraf, M; Champ, S; Holzapfel, BM; Clements, JA; Hutmacher, DW; Loessner, D (2017) -
A Validated Preclinical Animal Model for Primary Bone Tumor Research
Wagner, F; Holzapfel, BM; Thibaudeau, L; Straub, M; Ling, M-T; Grifka, J; Loessner, D; Levesque, J-P; Hutmacher, DW (2016-06-01)