Browsing Barts Cancer Institute by Title
Now showing items 100-119 of 1159
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Building invitro 3D human multicellular models of high-grade serous ovarian cancer.
(2022-03-18)Three-dimensional (3D), multicellular invitro models provide a useful platform for studying human cancer biology, particularly through deconvolution of the tumor microenvironment, or where animal models do not recapitulate ... -
Ca(2+)tapulting HSCs into action
(2018-08) -
CADM1 inhibits squamous cell carcinoma progression by reducing STAT3 activity.
(Springer Nature, 2016-04-01)Although squamous cell carcinomas (SqCCs) of the lungs, head and neck, oesophagus, and cervix account for up to 30% of cancer deaths, the mechanisms that regulate disease progression remain incompletely understood. Here, ... -
Cancer associated fibroblast FAK regulates malignant cell metabolism.
(2020-03-10)Emerging evidence suggests that cancer cell metabolism can be regulated by cancer-associated fibroblasts (CAFs), but the mechanisms are poorly defined. Here we show that CAFs regulate malignant cell metabolism through ... -
A cancer-associated, genome protective programme engaging PKCε.
(2020-12)Associated with their roles as targets for tumour promoters, there has been a long-standing interest in how members of the protein kinase C (PKC) family act to modulate cell growth and division. This has generated a great ... -
Carbon dating cancer: defining the chronology of metastatic progression in colorectal cancer.
(2017-06-01)BACKGROUND: Patients often ask oncologists how long a cancer has been present before causing symptoms or spreading to other organs. The evolutionary trajectory of cancers can be defined using phylogenetic approaches but ...