Browsing Barts Cancer Institute by Title
Now showing items 1115-1134 of 1159
-
Tumour associated macrophage recruitment in SCC
(2017-10) -
Tumour Cell Heterogeneity.
(2016)The population of cells that make up a cancer are manifestly heterogeneous at the genetic, epigenetic, and phenotypic levels. In this mini-review, we summarise the extent of intra-tumour heterogeneity (ITH) across human ... -
UKALLXII/ECOG2993: addition of imatinib to a standard treatment regimen enhances long-term outcomes in Philadelphia positive acute lymphoblastic leukemia.
(2014-02-06)The Philadelphia chromosome positive arm of the UKALLXII/ECOG2993 study for adult acute lymphoblastic leukemia (ALL) enrolled 266 patients between 1993 and 2003 (pre-imatinib cohort). In 2003 imatinib was introduced as a ... -
Unconventional role of RAC1 in MET-driven anchorage-independent tumor growth.
(2020-08-18)We reported that RAC1 is a master regulator of cell migration and anchorage-independent growth, downstream of the oncogenic Receptor Tyrosine Kinase (RTK) MET. RAC1 growth-promoting role is guanosine triphosphatase (GTPase)- ... -
Uncoupling TORC2 from AGC kinases inhibits tumour growth
(2017-10-17) -
Understanding and managing the cardiovascular risks of androgen deprivation therapy for prostate cancer
(Nature Research, 2022-10-24) -
Unravelling the pharmacologic opportunities and future directions for targeted therapies in gastro-intestinal cancers part 2: Neuroendocrine tumours, hepatocellular carcinoma, and gastro-intestinal stromal tumours.
(2018-01)Until the 1990s, cytotoxic chemotherapy has been the cornerstone of medical therapy for gastrointestinal (GI) cancers. Better understanding of the cancer cell molecular biology has led to the therapeutic revolution of ... -
An unusual cause of gastrointestinal bleeding: duodenal lipoma.
(2011-04-13)Common causes of chronic upper gastrointestinal bleeding include oesophageal varices, gastroduodenal ulcers and malignancy, and patients mostly present with iron deficiency type anaemia. We present the case of a 60-year-old ...