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Now showing items 21-30 of 83
Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking.
(2017)
The slow delayed-rectifier potassium current (IKs) is crucial for human cardiac action potential repolarization. The formation of IKs requires co-assembly of the KCNQ1 α-subunit and KCNE1 β-subunit, and mutations in either ...
Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K+ currents in adult murine atria.
(2018-05-01)
G protein-gated inwardly rectifying K+ (GIRK) channels are the major inwardly rectifying K+ currents in cardiac atrial myocytes and an important determinant of atrial electrophysiology. Inhibitory G protein α-subunits can ...
Have the Findings from Clinical Risk Prediction and Trials Any Key Messages for Safety Pharmacology?
(2017)
Anti-arrhythmic drugs are a mainstay in the management of symptoms related to arrhythmias, and are adjuncts in prevention and treatment of life-threatening ventricular arrhythmias. However, they also have the potential for ...
Functional Studies of TRPM7-a Candidate Gene for Stillbirth?
(Federation of American Society of Experimental Biology (FASEB), 2017-04-01)
ATP-sensitive potassium channels in the sinoatrial node contribute to heart rate control and adaptation to hypoxia.
(2018-06-08)
ATP-sensitive potassium channels (KATP) contribute to membrane currents in many tissues, are responsive to intracellular metabolism, and open as ATP falls and ADP rises. KATP channels are widely distributed in tissues and ...