Have the Findings from Clinical Risk Prediction and Trials Any Key Messages for Safety Pharmacology?
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Volume
8
Pagination
890 - ?
DOI
10.3389/fphys.2017.00890
Journal
Front Physiol
ISSN
1664-042X
Metadata
Show full item recordAbstract
Anti-arrhythmic drugs are a mainstay in the management of symptoms related to arrhythmias, and are adjuncts in prevention and treatment of life-threatening ventricular arrhythmias. However, they also have the potential for pro-arrhythmia and thus the prediction of arrhythmia predisposition and drug response are critical issues. Clinical trials are the latter stages in the safety testing and efficacy process prior to market release, and as such serve as a critical safeguard. In this review, we look at some of the lessons to be learned from approaches to arrhythmia prediction in patients, clinical trials of drugs used in the treatment of arrhythmias, and the implications for the design of pre-clinical safety pharmacology testing.