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The association of lyme disease with loss of sexual libido and the role of urinary bladder detrusor dysfunction.
(2014-06)
PURPOSE: The primary aim was to carry out a pilot study to compare the loss of sexual libido between a group of Lyme disease patients and a group of matched controls. The secondary aim was to evaluate whether loss of libido ...
Urinary bladder detrusor dysfunction symptoms in lyme disease.
(2013-09)
PURPOSE: Symptoms of urinary bladder detrusor dysfunction have been rarely reported in Lyme disease. The aim was to carry out the first systematic study to compare the prevalence of such symptoms in a group of Lyme disease ...
Potassium channels in the sinoatrial node and their role in heart rate control.
(2018)
Potassium currents determine the resting membrane potential and govern repolarisation in cardiac myocytes. Here, we review the various currents in the sinoatrial node focussing on their molecular and cellular properties ...
EU-funded initiatives for real world evidence: descriptive analysis of their characteristics and relevance for regulatory decision-making.
(2018-06-14)
INTRODUCTION: A review of European Union (EU)-funded initiatives linked to 'Real World Evidence' (RWE) was performed to determine whether their outputs could be used for the generation of real-world data able to support ...
Pharmacological Modulation of Right Ventricular Endocardial-Epicardial Gradients in Brugada Syndrome.
(2018-09)
Background We explored the hypothesis that increased cholinergic tone exerts its proarrhythmic effects in Brugada syndrome (BrS) through increasing dispersion of transmural repolarization in patients with spontaneous and ...
Modulation of Cardiac Ventricular Excitability by GLP-1 (Glucagon-Like Peptide-1).
(2018-10)
BACKGROUND: Glucagon-like peptide-1 receptor (GLP-1R) agonists improve cardiovascular outcomes in patients with type 2 diabetes mellitus. However, systemic actions of these agents cause sympathetic activation, which is ...
Topical Beta-Blockers and Cardiovascular Mortality: Systematic Review and Meta-Analysis with Data from the EPIC-Norfolk Cohort Study.
(2016-10)
PURPOSE: To determine if topical beta-blocker use is associated with increased cardiovascular mortality, particularly among people with self-reported glaucoma. METHODS: All participants who participated in the first health ...
Sex differences in the nitrate-nitrite-NO• pathway: Role of oral nitrate-reducing bacteria.
(2018-10)
Oral reduction of nitrate to nitrite is dependent on the oral microbiome and is the first step of an alternative mammalian pathway to produce nitric oxide in humans. Preliminary evidence suggests important sex differences ...
A Framework for Multi-Omic Prediction of Treatment Response to Biologic Therapy for Psoriasis.
(2019-01)
Biologic therapies have shown high efficacy in psoriasis, but individual response varies and is poorly understood. To inform biomarker discovery in the Psoriasis Stratification to Optimise Relevant Therapy (i.e., PSORT) ...