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Potassium channels in the sinoatrial node and their role in heart rate control.
(2018)
Potassium currents determine the resting membrane potential and govern repolarisation in cardiac myocytes. Here, we review the various currents in the sinoatrial node focussing on their molecular and cellular properties ...
Pharmacological Modulation of Right Ventricular Endocardial-Epicardial Gradients in Brugada Syndrome.
(2018-09)
Background We explored the hypothesis that increased cholinergic tone exerts its proarrhythmic effects in Brugada syndrome (BrS) through increasing dispersion of transmural repolarization in patients with spontaneous and ...
Modulation of Cardiac Ventricular Excitability by GLP-1 (Glucagon-Like Peptide-1).
(2018-10)
BACKGROUND: Glucagon-like peptide-1 receptor (GLP-1R) agonists improve cardiovascular outcomes in patients with type 2 diabetes mellitus. However, systemic actions of these agents cause sympathetic activation, which is ...
A critical role for the ATP-sensitive potassium channel subunit KIR6.1 in the control of cerebral blood flow.
(2018-06-04)
KIR6.1 (KCNJ8) is a subunit of ATP sensitive potassium channel (KATP) that plays an important role in the control of peripheral vascular tone and is highly expressed in brain contractile cells (vascular smooth muscle cells ...
Postmortem Genetic Testing for Cardiac Ion Channelopathies in Stillbirths.
(2018-01)
BACKGROUND: Although stillbirth is a significant health problem worldwide, the definitive cause of death remains elusive in many cases, despite detailed autopsy. In this study of partly explained and unexplained stillbirths, ...
Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system.
(2018-05-16)
Impaired capacity to increase heart rate (HR) during exercise (ΔHRex), and a reduced rate of recovery post-exercise (ΔHRrec) are associated with higher cardiovascular mortality rates. Currently, the genetic basis of both ...
Defective Vagal Innervation in Murine Tbx1 Mutant Hearts.
(2018-09-23)
Haploinsufficiency of the T-box transcription factor TBX1 is responsible for many features of 22q11.2 deletion syndrome. Tbx1 is expressed dynamically in the pharyngeal apparatus during mouse development and Tbx1 homozygous ...
Correction: Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort (vol 12, e0183732, 2017)
(Public Library of Science, 2018-02-12)
The following information is omitted from the Funding section: This research has been conducted using the UK Biobank Resource under Application Number 8256 and supported in part by Medical Research Council grant MR/N025083/1.