Centre for Translational Medicine & Therapeutics: Recent submissions
Now showing items 261-280 of 844
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Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial.
(2021-07-12)PURPOSE: To study the efficacy of lopinavir-ritonavir and hydroxychloroquine in critically ill patients with coronavirus disease 2019 (COVID-19). METHODS: Critically ill adults with COVID-19 were randomized to receive ... -
Relationship between the Clinical Frailty Scale and short-term mortality in patients ≥ 80 years old acutely admitted to the ICU: a prospective cohort study.
(2021-07-01)BACKGROUND: The Clinical Frailty Scale (CFS) is frequently used to measure frailty in critically ill adults. There is wide variation in the approach to analysing the relationship between the CFS score and mortality after ... -
Ethnicity and acute hospital admissions: Multi-center analysis of routine hospital data
(2021-08-19)Background: The effects of ethnic and social inequalities on patient outcomes in acute healthcare remain poorly understood. Methods: Prospectively-defined analysis of registry data from four acute NHS hospitals in east ... -
Enhanced postoperative surveillance versus standard of care to reduce mortality among adult surgical patients in Africa (ASOS-2): a cluster-randomised controlled trial
Background: Risk of mortality following surgery in patients across Africa is twice as high as the global average. Most of these deaths occur on hospital wards after the surgery itself. We aimed to assess whether enhanced ... -
The future of acute and emergency care.
(Royal College of Physicians, 2021-07-07)Improved outcomes for acutely unwell patients are predicated on early identification of deterioration, accelerating the time to accurate diagnosis of the underlying condition, selection and titration of treatments that ... -
Ethnic disparities in hospitalisation and hospital-outcomes during the second wave of COVID-19 infection in east London
(2021-07-07)This article is a preprint and has not been peer-reviewed. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice. ABSTRACT Objectives To determine if changes ... -
Multidrug resistance proteins preferentially regulate natriuretic peptide-driven cGMP signalling in the heart & vasculature.
(2021-06-15)BACKGROUND & PURPOSE: Cyclic-3',5'-guanosine monophosphate (cGMP) underpins the bioactivity of nitric oxide (NO) and natriuretic peptides and is key to cardiovascular homeostasis. Cyclic GMP-driven responses are terminated ... -
Head and neck cancer surgery during the COVID-19 pandemic: An international, multicenter, observational cohort study.
(Wiley Periodicals LLC on behalf of American Cancer Society, 2021-07-15)BACKGROUND: The aims of this study were to provide data on the safety of head and neck cancer surgery currently being undertaken during the coronavirus disease 2019 (COVID-19) pandemic. METHODS: This international, ... -
Acute hyperglycaemic crisis after vaccination against COVID-19: A case series.
(2021-06-29)Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are the most important component of the global response to the COVID-19 pandemic. Although most adverse reactions observed have been mild, the ... -
Acute kidney injury in the critically ill: an updated review on pathophysiology and management.
(2021-07-02)Acute kidney injury (AKI) is now recognized as a heterogeneous syndrome that not only affects acute morbidity and mortality, but also a patient's long-term prognosis. In this narrative review, an update on various aspects ...