Browsing Centre for Translational Medicine & Therapeutics by Subject "T cell"
Now showing items 1-5 of 5
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Human CD8+ EMRA T cells display a senescence-associated secretory phenotype regulated by p38 MAPK.
(2018-02)Cellular senescence is accompanied by a senescence-associated secretory phenotype (SASP). We show here that primary human senescent CD8+ T cells also display a SASP comprising chemokines, cytokines and extracellular matrix ... -
Mitochondrial Dysfunction Accelerates Ageing.
(2020-10-16)We review here the seminal findings of Desdin-Mico et al. showing that T cells with dysfunctional mitochondria induce multimorbity and premature senescence, due to mitochondrial transcription factor A (TFAM). They add ... -
Mitochondrial mass governs the extent of human T cell senescence
(Wiley Online, 2019-12-02)The susceptibility of human CD4+ and CD8+ T cells to senesce differs, with CD8+ T cells acquiring an immunosenescent phenotype faster than the CD4+ T cell compartment. We show here that it is the inherent difference in ...