Human CD8+ EMRA T cells display a senescent-associated secretory phenotype regulated by p38 MAPK.
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Cellular senescence is accompanied by a senescence-associated secretory phenotype (SASP). We show here that primary human senescent CD8+ T cells also display a SASP comprising of chemokines, cytokines and extracellular matrix remodelling proteases that are unique to this subset and contributes to age-associated inflammation. We found the CD8+ CD45RA+CD27- EMRA subset to be the most heterogeneous, with a population aligning with the naïve T cells and another with a closer association to the effector memory subset. However despite the differing processes that give rise to these senescent CD8+ T cells once generated they both adopt a unique secretory profile with no commonality to any other subset, aligning more closely with senescence than quiescence. Furthermore we also show that the SASP observed in senescent CD8+ T cells to be governed by p38 MAPK signaling.
AuthorsCallender, LA; carroll, EC; beal, R; Chambers, ES; Nourshargh, S; Akbar, AN; Henson, SM
- Inflammation