Browsing Centre for Translational Medicine & Therapeutics by Title
Now showing items 789-808 of 844
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Talking to multi-morbid patients about critical illness: an evolving conversation.
(2021-06-11)Conversations around critical illness outcomes and benefits from intensive care unit (ICU) treatment have begun to shift away from binary discussions on living versus dying. Increasingly, the reality of survival with ... -
Theatre efficiency: starting on time Reply
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TLR expression profiles are a function of disease status in rheumatoid arthritis and experimental arthritis.
(2021-01-22)The role of the innate immune system has been established in the initiation and perpetuation of inflammatory disease, but less attention has been paid to its role in the resolution of inflammation and return to homeostasis. ... -
TNFα inhibitors reduce bone loss in rheumatoid arthritis independent of clinical response by reducing osteoclast precursors and IL-20.
(2020-09-27)OBJECTIVES: About half of RA patients treated with TNFα inhibitors either do not respond or lose their initial therapeutic response over time. The clinical response is measured by reduction in DAS28, which primarily reflects ... -
Trans-auricular vagus nerve stimulation to reduce perioperative pain and morbidity: protocol for a single-blind analyser-masked randomised controlled trial.
(2022-06)BACKGROUND: Established or acquired loss of parasympathetic vagal tone is associated with complications, including pain, after noncardiac surgery. We describe a study protocol designed to test the hypothesis that transcutaneous ... -
Transauricular nerve stimulation in acute ischaemic stroke requiring mechanical thrombectomy: Protocol for a phase 2A, proof-of-concept, sham-controlled randomised trial.
(2023)BACKGROUND: Labile blood pressure after acute ischaemic stroke requiring mechanical thrombectomy is independently associated with poor patient outcomes. OBJECTIVES: This study protocol describes is designed to determine ... -
Transcription factors controlling E-cadherin downregulation in ovarian cancer
(2018-01-01)© The Author(s) 2018. Transcription factors (TFs), such as Snail, Slug and Twist, control the down-regulation of cell-cell adhesion molecule Ecadherin in ovarian cancer. Low E-cadherin aids tumour cells in undergoing ... -
Transcriptional response of the heart to vagus nerve stimulation.
(2023-12-04)Heart failure is a major clinical problem, with treatments involving medication, devices, and emerging neuromodulation therapies such as vagus nerve stimulation (VNS). Considering the ongoing interest in using VNS to treat ... -
Transcriptional response of the heart to vagus nerve stimulation.
(American Physiological Society, 2024-01-12)Heart failure is a major clinical problem, with treatments involving medication, devices, and emerging neuromodulation therapies such as vagus nerve stimulation (VNS). Considering the ongoing interest in using VNS to treat ... -
A Transcriptomic Approach to Understand Patient Susceptibility to Pneumonia After Abdominal Surgery.
(2023-07-27)OBJECTIVE: To describe immune-pathways and gene-networks altered following major-abdominal surgery and identify transcriptomic patterns associated with postoperative pneumonia. SUMMARY BACKGROUND DATA: Nosocomial infections ... -
Transient Receptor Potential Canonical Channels 4 and 5 Mediate Escherichia coli-Derived Thioredoxin Effects in Lipopolysaccharide-Injected Mice.
(2018)Thioredoxin plays an essential role in bacterial antioxidant machinery and virulence; however, its regulatory actions in the host are less well understood. Reduced human Trx activates transient receptor potential canonical ...