Browsing Centre for Translational Medicine & Therapeutics by Title
Now showing items 362-381 of 844
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Identification and validation of biomarkers of persistent acute kidney injury: the RUBY study.
(2020-02-06)PURPOSE: The aim of the RUBY study was to evaluate novel candidate biomarkers to enable prediction of persistence of renal dysfunction as well as further understand potential mechanisms of kidney tissue damage and repair ... -
Identification of AnnexinA1 as an endogenous regulator of RhoA, and its role in the pathophysiology and experimental therapy of type-2 diabetes.
(Frontiers Media, 2019-03-27)Annexin A1 (ANXA1) is an endogenously produced anti-inflammatory protein, which plays an important role in the pathophysiology of diseases associated with chronic inflammation. We demonstrate that patients with type-2 ... -
Immediate and sustained increases in the activity of vagal preganglionic neurons during exercise and after exercise training.
(2023-10-24)AIMS: The brain controls the heart by dynamic recruitment and withdrawal of cardiac parasympathetic (vagal) and sympathetic activity. Autonomic control is essential for the development of cardiovascular responses during ... -
The impact of extended bed rest on the musculoskeletal system in the critical care environment.
(2015)Prolonged immobility is harmful with rapid reductions in muscle mass, bone mineral density and impairment in other body systems evident within the first week of bed rest which is further exacerbated in individuals with ... -
The impact of frailty on ICU and 30-day mortality and the level of care in very elderly patients (≥ 80 years).
(Springer Berlin Heidelberg, 2017-09-21)PURPOSE: Very old critical ill patients are a rapid expanding group in the ICU. Indications for admission, triage criteria and level of care are frequently discussed for such patients. However, most relevant outcome studies ... -
Implications for post critical illness trial design: sub-phenotyping trajectories of functional recovery among sepsis survivors.
(2020-09-25)BACKGROUND: Patients who survive critical illness suffer from a significant physical disability. The impact of rehabilitation strategies on health-related quality of life is inconsistent, with population heterogeneity cited ... -
Improving care at scale: process evaluation of a multi-component quality improvement intervention to reduce mortality after emergency abdominal surgery (EPOCH trial).
(2018-11-13)BACKGROUND: Improving the quality and safety of perioperative care is a global priority. The Enhanced Peri-Operative Care for High-risk patients (EPOCH) trial was a stepped-wedge cluster randomised trial of a quality ...