Browsing Centre for Translational Medicine & Therapeutics by Title
Now showing items 325-344 of 844
-
A functional screen for regulators of CKDN2A reveals MEOX2 as a transcriptional activator of INK4a.
(Public Library of Science, 2009-04-02)The CDKN2A locus encodes two important tumor suppressors, INK4a and ARF, which respond to oncogenic stresses by inducing cellular senescence. We conducted a genome-scale cDNA overexpression screen using a reporter containing ... -
The future of acute and emergency care.
(Royal College of Physicians, 2021-07-07)Improved outcomes for acutely unwell patients are predicated on early identification of deterioration, accelerating the time to accurate diagnosis of the underlying condition, selection and titration of treatments that ... -
Gastrointestinal dysfunction in the critically ill: a systematic scoping review and research agenda proposed by the Section of Metabolism, Endocrinology and Nutrition of the European Society of Intensive Care Medicine.
(2020-05-15)BACKGROUND: Gastrointestinal (GI) dysfunction is frequent in the critically ill but can be overlooked as a result of the lack of standardization of the diagnostic and therapeutic approaches. We aimed to develop a research ... -
Graphene Oxide-Based Targeting of Extracellular Cathepsin D and Cathepsin L As A Novel Anti-Metastatic Enzyme Cancer Therapy
(MDPI AG, 2019-03-06)Overexpression and secretion of the enzymes cathepsin D (CathD) and cathepsin L (CathL) is associated with metastasis in several human cancers. As a superfamily, extracellularly, these proteins may act within the tumor ... -
Guanylyl cyclase can't stand the HETE
(2016-06-01) -
Guidelines on the management of acute respiratory distress syndrome.
(2019)The Faculty of Intensive Care Medicine and Intensive Care Society Guideline Development Group have used GRADE methodology to make the following recommendations for the management of adult patients with acute respiratory ...