Browsing Centre for Translational Medicine & Therapeutics by Title
Now showing items 21-40 of 844
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Acute Skeletal Muscle Wasting in Critical Illness
(American Medical Association, 2013-10-16)Importance Survivors of critical illness demonstrate skeletal muscle wasting with associated functional impairment. Objective To perform a comprehensive prospective characterization of skeletal muscle wasting, defining ... -
Adenosine signalling to astrocytes coordinates brain metabolism and function.
(2024-07-03)Brain computation performed by billions of nerve cells relies on a sufficient and uninterrupted nutrient and oxygen supply1,2. Astrocytes, the ubiquitous glial neighbours of neurons, govern brain glucose uptake and ... -
Administration of intrapulmonary sodium polyacrylate to induce lung injury for the development of a porcine model of early acute respiratory distress syndrome.
(2014-12)BACKGROUND: The loss of alveolar epithelial and endothelial integrity is a central component in acute respiratory distress syndrome (ARDS); however, experimental models investigating the mechanisms of epithelial injury are ... -
Admission serum myoglobin and the development of acute kidney injury after major trauma
(SpringerOpen, 2021-09-24)Background: Myoglobin and creatine kinase (CK) are both established markers of muscle injury but their hospital admission values have never been compared to predict post-traumatic acute kidney injury (AKI). Methods: An ... -
Advancements in nanomedicines for the detection and treatment of diabetic kidney disease.
(2022-06)In the diabetic kidneys, morbidities such as accelerated ageing, hypertension and hyperglycaemia create a pro-inflammatory microenvironment characterised by extensive fibrogenesis. Radiological techniques are not yet ... -
Age of patients undergoing surgery
(Wiley, 2019-05-22)Background Advancing age is independently associated with poor post-operative outcomes. The ageing of the general population is a major concern for healthcare providers. We studied trends in age amongst patients undergoing ... -
Aged-senescent cells contribute to impaired heart regeneration
(Wiley Online, 2019-03-10)Aging leads to increased cellular senescence and is associated with decreased potency of tissue‐specific stem/progenitor cells. Here, we have done an extensive analysis of cardiac progenitor cells (CPCs) isolated from human ... -
Aging and uremia: Is there cellular and molecular crossover?
(2015-02-06)Many observers have noted that the morphological changes that occur in chronic kidney disease (CKD) patients resemble those seen in the geriatric population, with strikingly similar morbidity and mortality profiles and ... -
American Society of Anesthesiologists Score: still useful after 60 years? Results of the EuSOS Study.
(2015)OBJECTIVE: The European Surgical Outcomes Study described mortality following in-patient surgery. Several factors were identified that were able to predict poor outcomes in a multivariate analysis. These included age, ...