Browsing Centre for Microvascular Research (CMR) by Author "De Rossi, G"
Now showing items 1-9 of 9
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Antibody-mediated inhibition of syndecan-4 dimerisation reduces interleukin (IL)-1 receptor trafficking and signalling.
Godmann, L; Bollmann, M; Korb-Pap, A; König, U; Sherwood, J; Beckmann, D; Mühlenberg, K; Echtermeyer, F; Whiteford, J; De Rossi, G (BMJ Publishing Group, 2020-04)OBJECTIVE: Syndecan-4 (sdc4) is a cell-anchored proteoglycan that consists of a transmembrane core protein and glucosaminoglycan (GAG) side chains. Binding of soluble factors to the GAG chains of sdc4 may result in the ... -
Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation
Reglero, N; Pérez-Gutiérrez, L; Yoshimura, A; Rolas, L; Garrido-Mesa, J; Barkaway, A; PICKWORTH, C; Saleeb, R; Gonzalez-Nuñez, M; Austin-Williams, SN (Elsevier, 2021-08-06)The migration of neutrophils from the blood circulation to sites of infection or injury is a key immune response and requires the breaching of endothelial cells (ECs) that line the inner aspect of blood vessels. ... -
CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis.
Tsoyi, K; Liang, X; De Rossi, G; Ryter, SW; Xiong, K; Chu, SG; Liu, X; Ith, B; Celada, LJ; Romero, F (2021-03-30)RATIONALE: The receptor-like protein tyrosine phosphatase eta (CD148/PTPRJ) exerts anti-fibrotic effects in experimental pulmonary fibrosis via interactions with its ligand syndecan-2; however, the role of CD148 in human ... -
Mutually Supportive Mechanisms of Inflammation and Vascular Remodeling
Whiteford, JR; De Rossi, G; Woodfin, A (2016) -
A novel role for syndecan-3 in angiogenesis.
De Rossi, G; Whiteford, JR (2013)Syndecan-3 is one of the four members of the syndecan family of heparan sulphate proteoglycans and has been shown to interact with numerous growth factors via its heparan sulphate chains. The extracellular core proteins ... -
Pathological Angiogenesis Requires Syndecan-4 for Efficient VEGFA-Induced VE-Cadherin Internalization
De Rossi, G; Vahatupa, M; Cristante, E; Arokiasamy, S; Liyanage, SE; May, U; Pellinen, L; Uusitalo-Jarvinen, H; Bainbridge, JW; Jarvinen, TAH (American Heart Association, 2021-02-18)Objective: VEGFA (Vascular endothelial growth factor A) and its receptor VEGFR2 (vascular endothelial growth factor receptor 2) drive angiogenesis in several pathologies, including diabetic retinopathy, wet age-related ... -
Shed syndecan-2 inhibits angiogenesis
De Rossi, G; Evans, AR; Kay, E; Woodfin, A; McKay, TR; Nourshargh, S; Whiteford, JR (2014-11-01) -
Syndecan-3 in Inflammation and Angiogenesis
Arokiasamy, S; Balderstone, MJM; De Rossi, G; Whiteford, JR (2020-01-09) -
Syndecans in angiogenesis and endothelial cell biology
De Rossi, G; Whiteford, JR (2014-12)