Browsing Centre for Microvascular Research (CMR) by Title
Now showing items 71-90 of 105
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On-site fabrication of Bi-layered adhesive mesenchymal stromal cell-dressings for the treatment of heart failure.
(2019-07)Mesenchymal stromal/stem cell (MSC)-based therapy is a promising approach for the treatment of heart failure. However, current MSC-delivery methods result in poor donor cell engraftment, limiting the therapeutic efficacy. ... -
Pathological Angiogenesis Requires Syndecan-4 for Efficient VEGFA-Induced VE-Cadherin Internalization
(American Heart Association, 2021-02-18)Objective: VEGFA (Vascular endothelial growth factor A) and its receptor VEGFR2 (vascular endothelial growth factor receptor 2) drive angiogenesis in several pathologies, including diabetic retinopathy, wet age-related ... -
Reparative Macrophage Transplantation for Myocardial Repair: A Refinement of Bone Marrow Mononuclear Cell-Based Therapy
(2019-08-02)Meeting Abstract: 718 from 14th Annual American-Heart-Association's Basic Cardiovascular Sciences (BCVS) Scientific Sessions , Boston, MA. JUL 29-AUG 01, 2019 -
The role of CD44 in the pathophysiology of chronic lymphocytic leukemia
(Frontiers Media, 2015-04-20)CD44 interactions with hyaluronan (HA) play a key role in various malignancies, supporting tumor cell migration, adhesion, and survival. In contrast to solid tumors, the expression of CD44 standard and variant forms and ... -
Self-assembling peptide hydrogel enables instant epicardial coating of the heart with mesenchymal stromal cells for the treatment of heart failure
(Elsevier, 2018-02-01)Transplantation of mesenchymal stromal cells (MSCs) is an emerging therapy for the treatment of heart failure. However, the delivery method of MSC is currently suboptimal. The use of self-assembling peptide hydrogels, ... -
Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues
(EMBO Press, 2024-06-25)Cellular senescence is a hallmark of advanced age and a major instigator of numerous inflammatory pathologies. Whilst endothelial cell (EC) senescence is aligned with defective vascular functionality, its impact on fundamental ...