Browsing Centre for Microvascular Research (CMR) by Title
Now showing items 84-103 of 105
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The role of CD44 in the pathophysiology of chronic lymphocytic leukemia
(Frontiers Media, 2015-04-20)CD44 interactions with hyaluronan (HA) play a key role in various malignancies, supporting tumor cell migration, adhesion, and survival. In contrast to solid tumors, the expression of CD44 standard and variant forms and ... -
Self-assembling peptide hydrogel enables instant epicardial coating of the heart with mesenchymal stromal cells for the treatment of heart failure
(Elsevier, 2018-02-01)Transplantation of mesenchymal stromal cells (MSCs) is an emerging therapy for the treatment of heart failure. However, the delivery method of MSC is currently suboptimal. The use of self-assembling peptide hydrogels, ... -
Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues
(EMBO Press, 2024-06-25)Cellular senescence is a hallmark of advanced age and a major instigator of numerous inflammatory pathologies. Whilst endothelial cell (EC) senescence is aligned with defective vascular functionality, its impact on fundamental ... -
Shed syndecan-2 inhibits angiogenesis
(2014-11-01) -
Syndecan receptors: pericellular regulators in development and inflammatory disease.
(The Royal Society, 2021-02-10)The syndecans are the major family of transmembrane proteoglycans, usually bearing multiple heparan sulfate chains. They are present on virtually all nucleated cells of vertebrates and are also present in invertebrates, ... -
Syndecan-3 in Inflammation and Angiogenesis
(2020-01-09) -
TCL1 transgenic mice as a model for CD49d-high chronic lymphocytic leukemia
(Springer Nature, 2020-02-21) -
TIGIT expressing CD4+T cells represent a tumor-supportive T cell subset in chronic lymphocytic leukemia
(Taylor & Francis, 2017-09-21)While research on T cell exhaustion in context of cancer particularly focuses on CD8C cytotoxic T cells, the role of inhibitory receptors on CD4C T-helper cells have remained largely unexplored. TIGIT is a recently identified ... -
Tuning the endothelial response: differential release of exocytic cargos from Weibel-Palade Bodies.
(Wiley, 2018-06-28)BACKGROUND: Endothelial cells harbour specialised storage organelles, Weibel-Palade Bodies (WPBs). Exocytosis of WPB content into the vascular lumen initiates primary haemostasis, mediated by Von Willebrands factor (VWF) ...