Browsing Centre for Biochemical Pharmacology by Title
Now showing items 238-257 of 332
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Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component.
(EMBO Press, 2021-05-25)Pancreatic ductal adenocarcinoma (PDAC) patients frequently suffer from undetected micro-metastatic disease. This clinical situation would greatly benefit from additional investigation. Therefore, we set out to identify ... -
PCR Assembly of Synthetic Promoters.
(2017)In this chapter, we describe a two-step assembly PCR method to construct synthetic promoters. Essentially, this method takes advantage of specific annealing between complimentary DNA sequences to build random TFBS combinations ... -
Polyunsaturated fatty acids modify the extracellular vesicle membranes and increase the production of proresolving lipid mediators of human mesenchymal stromal cells.
(2019-10)Human mesenchymal stromal/stem cells (hMSCs) are used in experimental cell therapy to treat various immunological disorders, and the extracellular vesicles (hMSC-EVs) they produce have emerged as an option for cell-free ... -
Post-COVID symptoms reported at asynchronous virtual review and stratified follow-up after COVID-19 pneumonia.
(Royal College of Physicians, 2021-06-08)BACKGROUND: The COVID-19 pandemic has strained healthcare systems and how best to address post-COVID health needs is uncertain. Here we describe the post-COVID symptoms of 675 patients followed up using a virtual review ... -
Pro-Resolving Mediators in Regulating and Conferring Macrophage Function.
(2017)Macrophages are central in coordinating the host response to both sterile and infective insults. Clearance of apoptotic cells and cellular debris is a key biological action preformed by macrophages that paves the way to ... -
Pro-resolving mediators promote resolution in a human skin model of UV-killed Escherichia coli-driven acute inflammation.
(2018-03-22)While the treatment of inflammatory disorders is generally based on inhibiting factors that drive onset of inflammation, these therapies can compromise healing (NSAIDs) or dampen immunity against infections (biologics). ... -
A pro-resolving role for Galectin-1 in acute inflammation
(Frontiers Media, 2020-03-20)Galectin-1 (Gal-1) exerts immune-regulatory and anti-inflammatory actions in animal models of acute and chronic inflammation. Its release into the extracellular milieu often correlates with the peak of inflammation suggesting ... -
Prolonged immune alteration following resolution of acute inflammation in humans.
(2017)Acute inflammation is an immediate response to infection and injury characterised by the influx of granulocytes followed by phagocytosing mononuclear phagocytes. Provided the antigen is cleared and the immune system of the ... -
Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis.
(2016-04-21)Rheumatoid arthritis (RA) is a debilitating disease characterized by persistent accumulation of leukocytes within the articular cavity and synovial tissue. Metabololipidomic profiling of arthritic joints from omega-3 ...