Browsing Centre for Biochemical Pharmacology by Title
Now showing items 177-196 of 332
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Intracellular sodium elevation reprograms cardiac metabolism.
(2020-08-28)Intracellular Na elevation in the heart is a hallmark of pathologies where both acute and chronic metabolic remodelling occurs. Here, we assess whether acute (75 μM ouabain 100 nM blebbistatin) or chronic myocardial Nai ... -
The Isoform Selective Roles of PI3Ks in Dendritic Cell Biology and Function.
(2018)Phosphoinositide-3 kinases (PI3Ks) generate 3-phosphorylated phosphoinositide lipids that are implicated in many biological processes in homeostatic states and pathologies such as cancer, inflammation and autoimmunity. ... -
Isolation of stromal vascular fraction cell suspensions from mouse and human adipose tissues for downstream applications.
(2021-06-18)This protocol outlines a reliable and versatile approach to isolate stromal vascular fraction cells from different adipose tissues across human and mouse species. A number of downstream applications can then be performed ... -
Leukocytes from obese individuals exhibit an impaired SPM signature.
(2019-06)Specialized proresolving mediators (SPMs) biosynthesized from docosahexaenoic acids (DHAs) including resolvins (Rvs), protectins, and maresins are potent endogenous autacoids that actively resolve inflammation, protect ... -
Ligand Bias and Its Association With Pro-resolving Actions of Melanocortin Drugs.
(2018)Resolution Pharmacology identifies drugs developed on the biology of the resolution phase of inflammation, the complex molecular and cellular network of events that ensure the tight temporal and spatial control on the ... -
Lipid Mediator Metabolomics Via LC-MS/MS Profiling and Analysis.
(2018)Solid-phase extraction coupled with liquid chromatography tandem mass spectrometry provides a robust and sensitive approach for the identification and quantitation of specialized pro-resolving mediators (lipoxins, resolvins, ... -
Lipid mediators in platelet concentrate and extracellular vesicles: Molecular mechanisms from membrane glycerophospholipids to bioactive molecules.
(2019-08)Platelets are collected for transfusion to patients with different haematological disorders, and for logistical reasons, platelets are stored as concentrates. Despite carefully controlled conditions, platelets become ... -
Lipid mediators of inflammation and Resolution in individuals with tuberculosis and tuberculosis-Diabetes.
(Elsevier, 2019-11-11)Individuals with concurrent tuberculosis (TB) and Type 2 diabetes (DM) have a higher risk of adverse outcomes. To better understand potential immunological differences, we utilized a comprehensive panel to characterize ... -
The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease.
(Elsevier, 2021-08-17)Persistent ill health after acute COVID-19-referred to as long COVID, the post-acute COVID-19 syndrome, or the post-COVID-19 condition-has emerged as a major concern. We undertook an international consensus exercise to ... -
The low-density lipoprotein receptor (LDL-R) is an immune-metabolic checkpoint during CD8 T Lymphocytes activation
(2021-08-01)Meeting abstract