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Impaired IL‐27 Mediated Control of CD4+ T Cell Function Impacts on Ectopic Lymphoid Structure Formation in Patients with Sjögren's Syndrome
(Wiley, 2020-04-20)
This is the pre-peer reviewed version of the following article: Lucchesi, D., Coleby, R., Pontarini, E., Prediletto, E., Rivellese, F., Hill, D.G., Derrac Soria, A., Jones, S.A., Humphreys, I.R., Sutcliffe, N., Tappuni, ...
Tertiary Lymphoid Organs in Rheumatoid Arthritis.
(2020)
Rheumatoid Arthritis (RA) is a chronic systemic autoimmune disease. RA mainly affects the joints, with inflammation of the synovial membrane, characterized by hyperplasia, neo-angiogenesis, and immune cell infiltration ...
Unique expansion of IL-21+ Tfh and Tph cells under control of ICOS identifies Sjögren's syndrome with ectopic germinal centres and MALT lymphoma.
(2020-09-22)
OBJECTIVES: To explore the relevance of T-follicular-helper (Tfh) and pathogenic peripheral-helper T-cells (Tph) in promoting ectopic lymphoid structures (ELS) and B-cell mucosa-associated lymphoid tissue (MALT) lymphomas ...