Browsing Centre for Experimental Medicine and Rheumatology (EMR) by Subject "Gene Expression Regulation"
Now showing items 1-2 of 2
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Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution.
(2023-12)The human leukocyte antigen (HLA) locus plays a critical role in complex traits spanning autoimmune and infectious diseases, transplantation and cancer. While coding variation in HLA genes has been extensively documented, ... -
TNFα in the regulation of Treg and Th17 cells in rheumatoid arthritis and other autoimmune inflammatory diseases.
(2018-01)TNFα is a principal pro-inflammatory cytokine vital for immunity to infections. However, its excessive production is involved in chronic inflammation and disease pathology in autoimmune diseases. Evidence for its pathogenic ...