Browsing Centre for Experimental Medicine and Rheumatology (EMR) by Author "Taher, TE"
Now showing items 1-6 of 6
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Association of Defective Regulation of Autoreactive Interleukin-6-Producing Transitional B Lymphocytes With Disease in Patients With Systemic Sclerosis.
Taher, TE; Ong, VH; Bystrom, J; Hillion, S; Simon, Q; Denton, CP; Pers, J-O; Abraham, DJ; Mageed, RA (2018-03)OBJECTIVE: Systemic sclerosis (SSc) has the highest case-specific mortality of any rheumatic disease, and no effective therapy is available. A clear manifestation of SSc is the presence of autoantibodies. However, the ... -
CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes.
Garaud, S; Taher, TE; Debant, M; Burgos, M; Melayah, S; Berthou, C; Parikh, K; Pers, J-O; Luque-Paz, D; Chiocchia, G (2018-02)CD5 is constitutively expressed on T cells and a subset of mature normal and leukemic B cells in patients with chronic lymphocytic leukemia (CLL). Important functional properties are associated with CD5 expression in B ... -
Functional and phenotypic heterogeneity of Th17 cells in health and disease
Bystrom, J; Clanchy, FIL; Taher, TE; Al-Bogami, M; Ong, VH; Abraham, DJ; Williams, RO; Mageed, RA (2019-01) -
Harnessing the Therapeutic Potential of Th17 Cells
Bystrom, J; Taher, TE; Muhyaddin, MS; Clanchy, FI; Mangat, P; Jawad, AS; Williams, RO; Mageed, RA (2015) -
Response to Treatment with TNF alpha Inhibitors in Rheumatoid Arthritis Is Associated with High Levels of GM-CSF and GM-CSF+ T Lymphocytes
Bystrom, J; Clanchy, FI; Taher, TE; Al-Bogami, MM; Muhammad, HA; Alzabin, S; Mangat, P; Jawad, AS; Williams, RO; Mageed, RA (2017-10) -
TNFα in the regulation of Treg and Th17 cells in rheumatoid arthritis and other autoimmune inflammatory diseases.
Bystrom, J; Clanchy, FI; Taher, TE; Mangat, P; Jawad, AS; Williams, RO; Mageed, RA (2018-01)TNFα is a principal pro-inflammatory cytokine vital for immunity to infections. However, its excessive production is involved in chronic inflammation and disease pathology in autoimmune diseases. Evidence for its pathogenic ...