Browsing Centre for Experimental Medicine and Rheumatology (EMR) by Author "Szajna, M"
Now showing items 1-3 of 3
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Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages.
Ling, GS; Bennett, J; Woollard, KJ; Szajna, M; Fossati-Jimack, L; Taylor, PR; Scott, D; Franzoso, G; Cook, HT; Botto, M (Nature Research, 2014-01-15)Tuned and distinct responses of macrophages and dendritic cells to Toll-like receptor 4 (TLR4) activation induced by lipopolysaccharide (LPS) underpin the balance between innate and adaptive immunity. However, the molecule(s) ... -
Intranasal peptide-induced tolerance and linked suppression: consequences of complement deficiency.
Fossati-Jimack, L; Ling, GS; Baudino, L; Szajna, M; Manivannan, K; Zhao, JC; Midgley, R; Chai, J-G; Simpson, E; Botto, M (2015-01)A role for complement, particularly the classical pathway, in the regulation of immune responses is well documented. Deficiencies in C1q or C4 predispose to autoimmunity, while deficiency in C3 affects the suppression of ... -
Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells.
Fossati-Jimack, L; Ling, GS; Cortini, A; Szajna, M; Malik, TH; McDonald, JU; Pickering, MC; Cook, HT; Taylor, PR; Botto, M (2013)The CD11b/CD18 integrin (complement receptor 3, CR3) is a surface receptor on monocytes, neutrophils, macrophages and dendritic cells that plays a crucial role in several immunological processes including leukocyte ...