Browsing Centre for Experimental Medicine and Rheumatology (EMR) by Author "Pagani, S"
Now showing items 1-13 of 13
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Axl and MerTK regulate synovial inflammation and are modulated by IL-6 inhibition in rheumatoid arthritis.
Nerviani, A; Boutet, M-A; Ghirardi, GM; Goldmann, K; Sciacca, E; Rivellese, F; Pontarini, E; Prediletto, E; Abatecola, F; Caliste, M (2024-03-16)The TAM tyrosine kinases, Axl and MerTK, play an important role in rheumatoid arthritis (RA). Here, using a unique synovial tissue bioresource of patients with RA matched for disease stage and treatment exposure, we assessed ... -
FRI0271 Dimethyl fumarate inhibits ube2l3 mediated tlr7 signalling and autoreactive b cell development in sle
Mauro, D; Tsang, V; Lucey-Clayton, I; Rivellese, F; Pagani, S; Alam, F; Pontarini, E; Nerviani, A; Pakozdi, A; Rajakariah, R (2018-06-01) -
Increased plasma levels of Gas6 and its soluble tyrosine kinase receptors Mer and Axl are associated with immunological activity and severity of lupus nephritis.
Bellan, M; Quaglia, M; Nerviani, A; Mauro, D; Lewis, M; Goegan, F; Gibbin, A; Pagani, S; Salmi, L; Molinari, L (2020-06-04)OBJECTIVES: Growth arrest-specific 6 (Gas6) and its receptors have been shown to play a crucial role in the homeostasis of the innate immune system by regulating apoptosis and inflammation. We aimed to verify whether an ... -
Mast cells in early rheumatoid arthritis associate with disease severity and support B cell autoantibody production
Rivellese, F; Mauro, D; Nerviani, A; Pagani, S; Fossati-Jimack, L; Messemaker, T; Kurreeman, FAS; Toes, REM; Ramming, A; Rauber, S (2018-12) -
New Insights into the Role of Tyro3, Axl, and Mer Receptors in Rheumatoid Arthritis
Pagani, S; Bellan, M; Mauro, D; Castello, LM; Avanzi, GC; Lewis, MJ; Sainaghi, PP; Pitzalis, C; Nerviani, A (2020-01-21) -
Novel Bispecific Antibody for Synovial-Specific Target Delivery of Anti-TNF Therapy in Rheumatoid Arthritis.
Ferrari, M; Onuoha, SC; Fossati-Jimack, L; Nerviani, A; Alves, PL; Pagani, S; Deantonio, C; Colombo, F; Santoro, C; Sblattero, D (Frontiers Media, 2021-02-19)Biologic drugs, especially anti-TNF, are considered as the gold standard therapy in rheumatoid arthritis. However, non-uniform efficacy, incidence of infections, and high costs are major concerns. Novel tissue-specific ... -
Persistence of Mast Cell-Rich Synovitis Is Associated with Lack of Response to Synthetic Disease Modifying Anti-Rheumatic Drugs in Patients with Early Rheumatoid Arthritis
Rivellese, F; Humby, F; Pagani, S; Nerviani, A; Pitzalis, C (2017-10)ABSTRACT NUMBER 1401 from 2017 ACR/ARHP Annual Meeting -
Regulation of TLR7 Signalling By UBE2L3 Dependent Linear Ubiquitination Explains Dimethyl Fumarate Suppression of Autoreactive B Cell Development in SLE
Mauro, D; Tsang, V; Clayton-Lucey, IA; Pagani, S; Alam, F; Pontarini, E; Nerviani, A; Pakozdi, A; Cove-Smith, A; Rajakariar, R (2017-10) -
RESTRICTED AXL SYNOVIAL EXPRESSION AND INCREASED CLEAVAGE OF AXL ECTODOMAIN CORRELATE WITH HIGHLY INFLAMED SYNOVITIS AND MORE SEVERE RHEUMATOID ARTHRITIS
Nerviani, A; Mauro, D; Pagani, S; Lliso-Ribera, G; Rivellese, F; Lewis, M; Bombardieri, M; Humby, F; Pitzalis, C (2018-06) -
SYNOVIAL MAST CELLS AND RESPONSES TO SYNTHETIC AND BIOLOGIC DMARDS IN EARLY AND ESTABLISHED RHEUMATOID ARTHRITIS
Rivellese, F; Nerviani, A; Mauro, D; Pagani, S; Humby, F; Pitzalis, C (2018-06) -
SYNOVIAL MAST CELLS IDENTIFY PATIENTS WITH A SEVERE PHENOTYPE IN A COHORT OF DMARD NAIVE PATIENTS WITH EARLY RHEUMATOID ARTHRITIS
Rivellese, F; Humby, F; Nerviani, A; Pagani, S; Mauro, D; de Paulis, A; Marone, G; Pitzalis, C (2017-06) -
Tyrosine Kinase Receptor Axl Is Down Regulated in Highly Inflamed Rheumatoid Synovium and Negatively Correlates with Markers of Disease Activity
Nerviani, A; Pagani, S; Mauro, D; Humby, F; Kelly, S; Rivellese, F; Ribera, GL; Lewis, MJ; Bombardieri, M; Pitzalis, C (2017-10) -
UBE2L3 regulates TLR7-induced B cell autoreactivity in Systemic Lupus Erythematosus
Mauro, D; Manou-Stathopoulou, S; Rivellese, F; Sciacca, E; Goldmann, K; Tsang, V; Lucey-Clayton, I; Pagani, S; Alam, F; Pyne, D (2023)