Browsing Centre for Experimental Medicine and Rheumatology (EMR) by Author "Lewis, MJ"
Now showing items 1-20 of 47
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Activation of naive CD4(+) T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4(+) T cells
Twohig, JP; Figueras, AC; Andrews, R; Wiede, F; Cossins, BC; Soria, AD; Lewis, MJ; Townsend, MJ; Millrine, D; Li, J (2019-04) -
Analysis of Complement Gene Expression, Clinical Associations, and Biodistribution of Complement Proteins in the Synovium of Early Rheumatoid Arthritis Patients Reveals Unique Pathophysiologic Features
Banda, NK; Deane, KD; Bemis, EA; Strickland, C; Seifert, J; Jordan, K; Goldman, K; Morgan, BP; Moreland, LW; Lewis, MJ (2022) -
Autoantibodies targeting TLR and SMAD pathways define new subgroups in systemic lupus erythematosus
Lewis, MJ; McAndrew, MB; Wheeler, C; Workman, N; Agashe, P; Koopmann, J; Uddin, E; Morris, DL; Zou, L; Stark, R (2018-07) -
Axl and MerTK regulate synovial inflammation and are modulated by IL-6 inhibition in rheumatoid arthritis.
Nerviani, A; Boutet, M-A; Ghirardi, GM; Goldmann, K; Sciacca, E; Rivellese, F; Pontarini, E; Prediletto, E; Abatecola, F; Caliste, M (2024-03-16)The TAM tyrosine kinases, Axl and MerTK, play an important role in rheumatoid arthritis (RA). Here, using a unique synovial tissue bioresource of patients with RA matched for disease stage and treatment exposure, we assessed ... -
B Cell Synovitis and Clinical Phenotypes in Rheumatoid Arthritis: Relationship to Disease Stages and Drug Exposure.
Rivellese, F; Humby, F; Bugatti, S; Fossati-Jimack, L; Rizvi, H; Lucchesi, D; Lliso-Ribera, G; Nerviani, A; Hands, RE; Giorli, G (2019-11-29)OBJECTIVE: To define the relationship of synovial B cells to clinical phenotypes at different stages of disease evolution and drug exposure in rheumatoid arthritis (RA). METHODS: Synovial biopsy specimens and demographic ... -
BBmix: a Bayesian beta-binomial mixture model for accurate genotyping from RNA-sequencing
Vigorito, E; Barton, A; Pitzalis, C; Lewis, MJ; Wallace, C (2023) -
Circulating and Synovial Pentraxin-3 (PTX3) Expression Levels Correlate With Rheumatoid Arthritis Severity and Tissue Infiltration Independently of Conventional Treatments Response
Boutet, M-A; Nerviani, A; Lliso-Ribera, G; Leone, R; Sironi, M; Hands, R; Rivellese, F; Del Prete, A; Goldmann, K; Lewis, MJ (2021) -
CORRELATION OF SOLUBLE VASCULAR CELL ADHESION MOLECULE 1 WITH B CELL ACTIVATION AND PLASMA CELLS IN SYSTEMIC LUPUS ERYTHEMATOSUS
Lewis, MJ; Vyse, S; Shields, AM; Zou, L; Khamashta, M; Gordon, PA; Pitzalis, C; Vyse, TJ; D'Cruz, D (2016-04) -
Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes.
Zhang, F; Jonsson, AH; Nathan, A; Millard, N; Curtis, M; Xiao, Q; Gutierrez-Arcelus, M; Apruzzese, W; Watts, GFM; Weisenfeld, D (2023-11)Rheumatoid arthritis is a prototypical autoimmune disease that causes joint inflammation and destruction1. There is currently no cure for rheumatoid arthritis, and the effectiveness of treatments varies across patients, ... -
DEGGs: an R package with shiny app for the identification of differentially expressed gene-gene interactions in high-throughput sequencing data
Sciacca, E; Alaimo, S; Silluzio, G; Ferro, A; Latora, V; Pitzalis, C; Pulvirenti, A; Lewis, MJ (2023) -
Distinct roles for complement in glomerulonephritis and atherosclerosis revealed in mice with a combination of lupus and hyperlipidemia
Lewis, MJ; Malik, TH; Fossati-Jimack, L; Carassiti, D; Cook, HT; Haskard, DO; Botto, M (2012-08) -
Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis
Alivernini, S; MacDonald, L; Elmesmari, A; Finlay, S; Tolusso, B; Gigante, MR; Petricca, L; Di Mario, C; Bui, L; Perniola, S (2020-08) -
Diversity of NF-Kappa B signalling and inflammatory heterogeneity in Rheumatic Autoimmune Disease
Manou-Stathopoulou, S; Lewis, MJ (2021) -
DNA Methylation Signatures of Response to Conventional Synthetic and Biologic Disease-Modifying Antirheumatic Drugs (DMARDs) in Rheumatoid Arthritis
Wang, SS; Lewis, MJ; Pitzalis, C (2023) -
The effect of ethnicity and genetic ancestry on the epidemiology, clinical features and outcome of systemic lupus erythematosus
Lewis, MJ; Jawad, AS (2017-04) -
Effects of targeting the transcription factors Ikaros and Aiolos on B cell activation and differentiation in systemic lupus erythematosus
Rivellese, F; Manou-Stathopoulou, S; Mauro, D; Goldmann, K; Pyne, D; Rajakariar, R; Gordon, P; Schafer, P; Bombardieri, M; Pitzalis, C (2021) -
Expression and Functions of the Transcription Factors Ikaros and Aiolos in Sjogren's Syndrome and Systemic Lupus Erythematosus
Rivellese, F; Mauro, D; Congia, M; Pontarini, E; Schafer, P; Bombardieri, M; Pitzalis, C; Lewis, MJ (2018-09) -
Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis
El Shikh, MEM; El Sayed, R; Nerviani, A; Goldmann, K; John, CR; Hands, R; Fossati-Jimack, L; Lewis, MJ; Pitzalis, C (2019-12) -
Follicular dendritic cell differentiation is associated with distinct synovial pathotype signatures in rheumatoid arthritis
El Shikh, MEM; El Sayed, R; Aly, NAR; Prediletto, E; Hands, R; Fossati-Jimack, L; Bombardieri, M; Lewis, MJ; Pitzalis, C (2022) -
FRI0271 Dimethyl fumarate inhibits ube2l3 mediated tlr7 signalling and autoreactive b cell development in sle
Mauro, D; Tsang, V; Lucey-Clayton, I; Rivellese, F; Pagani, S; Alam, F; Pontarini, E; Nerviani, A; Pakozdi, A; Rajakariah, R (2018-06-01)