Browsing Centre for Experimental Medicine and Rheumatology (EMR) by Author "Knight, JC"
Now showing items 1-5 of 5
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Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study
Scicluna, BP; van Vught, LA; Zwinderman, AH; Wiewel, MA; Davenport, EE; Burnham, KL; Nurnberg, P; Schultz, MJ; Horn, J; Cremer, OL (2017) -
A community approach to mortality prediction in sepsis via gene expression analysis.
Sweeney, TE; Perumal, TM; Henao, R; Nichols, M; Howrylak, JA; Choi, AM; Bermejo-Martin, JF; Almansa, R; Tamayo, E; Davenport, EE (2018-02-15)Improved risk stratification and prognosis prediction in sepsis is a critical unmet need. Clinical severity scores and available assays such as blood lactate reflect global illness severity with suboptimal performance, and ... -
Multi-omics integration to characterise mechanisms of molecular QTL from a sepsis cohort
Milind, N; Burnham, KL; Lee, W; Mi, Y; Goh, C; Hinds, CJ; Knight, JC; Davenport, EE (2022) -
Shared and Distinct Aspects of the Sepsis Transcriptomic Response to Fecal Peritonitis and Pneumonia.
Burnham, KL; Davenport, EE; Radhakrishnan, J; Humburg, P; Gordon, AC; Hutton, P; Svoren-Jabalera, E; Garrard, C; Hill, AVS; Hinds, CJ (2017-08-01)RATIONALE: Heterogeneity in the septic response has hindered efforts to understand pathophysiology and develop targeted therapies. Source of infection, with different causative organisms and temporal changes, might influence ... -
Transcriptomic Signatures in Sepsis and a Differential Response to Steroids. From the VANISH Randomized Trial.
Antcliffe, DB; Burnham, KL; Al-Beidh, F; Santhakumaran, S; Brett, SJ; Hinds, CJ; Ashby, D; Knight, JC; Gordon, AC (2019-04-15)RATIONALE: There remains uncertainty about the role of corticosteroids in sepsis with clear beneficial effects on shock duration, but conflicting survival effects. Two transcriptomic sepsis response signatures (SRSs) have ...