Browsing Centre for Experimental Medicine and Rheumatology (EMR) by Author "Honjo, T"
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High pathogenic potential of low-affinity autoantibodies in experimental autoimmune hemolytic anemia.
Fossati-Jimack, L; Reininger, L; Chicheportiche, Y; Clynes, R; Ravetch, JV; Honjo, T; Izui, S (1999-12-06)To assess the potency of low-affinity anti-red blood cell (RBC) autoantibodies in the induction of anemia, we generated an immunoglobulin (Ig)G2a class-switch variant of a 4C8 IgM anti-mouse RBC autoantibody, and compared ... -
Markedly different pathogenicity of four immunoglobulin G isotype-switch variants of an antierythrocyte autoantibody is based on their capacity to interact in vivo with the low-affinity Fcgamma receptor III.
Fossati-Jimack, L; Ioan-Facsinay, A; Reininger, L; Chicheportiche, Y; Watanabe, N; Saito, T; Hofhuis, FM; Gessner, JE; Schiller, C; Schmidt, RE (2000-04-17)Using three different Fcgamma receptor (FcgammaR)-deficient mouse strains, we examined the induction of autoimmune hemolytic anemia by each of the four immunoglobulin (Ig)G isotype-switch variants of a 4C8 IgM antierythrocyte ...