Browsing Centre for Experimental Medicine and Rheumatology (EMR) by Author "Hofhuis, FM"
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Markedly different pathogenicity of four immunoglobulin G isotype-switch variants of an antierythrocyte autoantibody is based on their capacity to interact in vivo with the low-affinity Fcgamma receptor III.
Fossati-Jimack, L; Ioan-Facsinay, A; Reininger, L; Chicheportiche, Y; Watanabe, N; Saito, T; Hofhuis, FM; Gessner, JE; Schiller, C; Schmidt, RE (2000-04-17)Using three different Fcgamma receptor (FcgammaR)-deficient mouse strains, we examined the induction of autoimmune hemolytic anemia by each of the four immunoglobulin (Ig)G isotype-switch variants of a 4C8 IgM antierythrocyte ...