Browsing Centre for Experimental Medicine and Rheumatology (EMR) by Author "Humby, F"
Now showing items 21-40 of 46
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Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes
Lewis, MJ; Barnes, MR; Blighe, K; Goldmann, K; Rana, S; Hackney, JA; Ramamoorthi, N; John, CR; Watson, DS; Kummerfeld, SK (2019-08-27) -
A Multicenter Retrospective Analysis Evaluating Performance of Synovial Biopsy Techniques in Patients With Inflammatory Arthritis Arthroscopic Versus Ultrasound-Guided Versus Blind Needle Biopsy
Humby, F; Romao, VC; Manzo, A; Filer, A; Bugatti, S; Vieira-Sousa, E; Kelly, S; Wechalekar, M; Ahmed, M; Rocher, V (2018-05) -
O20 Histological and molecular features of the diseased synovium in early untreated PsA in comparison with RA
Nerviani, A; Lliso-Ribera, G; Boutet, M-A; Goldmann, K; Rivellese, F; Kelly, S; Bombardieri, M; Lewis, M; Humby, F; Pitzalis, C (2020-04-01) -
A Pauci-Immune Synovial Pathotype Predicts Inadequate Response to TNF alpha-Blockade in Rheumatoid Arthritis Patients
Nerviani, A; Di Cicco, M; Mahto, A; Lliso-Ribera, G; Rivellese, F; Thorborn, G; Hands, R; Bellan, M; Mauro, D; Boutet, M-A (2020-05-05) -
Persistence of B Cell-rich Synovitis Following Conventional Synthetic Disease Modifying Anti-Rheumatic Drug Treatment in Early Rheumatoid Arthritis Is Associated with Radiographic Progression Independently of Clinical Response
Rivellese, F; Lliso-Ribera, G; Nerviani, A; Humby, F; Pitzalis, C (2019) -
Persistence of Mast Cell-Rich Synovitis Is Associated with Lack of Response to Synthetic Disease Modifying Anti-Rheumatic Drugs in Patients with Early Rheumatoid Arthritis
Rivellese, F; Humby, F; Pagani, S; Nerviani, A; Pitzalis, C (2017-10)ABSTRACT NUMBER 1401 from 2017 ACR/ARHP Annual Meeting -
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients
Isaacs, JD; Brockbank, S; Pedersen, AW; Hilkens, C; Anderson, A; Stocks, P; Lendrem, D; Tarn, J; Smith, GR; Allen, B (2022) -
A Randomised, Open Labelled Clinical Trial to Investigate Synovial Mechanisms Determining Response - Resistance to Rituximab versus Tocilizumab in Rheumatoid Arthritis Patients Failing TNF Inhibitor Therapy
Humby, F; Buch, MH; Durez, P; Lewis, M; Bombardieri, M; Rizvi, H; Kelly, S; Fosatti, L; Hands, R; Giorli, G (2019-10) -
The Relationship Between Synovial Pathobiology and Magnetic Resonance Imaging Abnormalities in Rheumatoid Arthritis: A Systematic Review
Humby, F; Mahto, A; Ahmed, M; Barr, A; Kelly, S; Buch, M; Pitzalis, C; Conaghan, PG (2017-09-01) -
Response to 'Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients' by Humby et al.
Humby, F; Lewis, M; Townsend, MJ; Pitzalis, C (2019-07-13) -
RESTRICTED AXL SYNOVIAL EXPRESSION AND INCREASED CLEAVAGE OF AXL ECTODOMAIN CORRELATE WITH HIGHLY INFLAMED SYNOVITIS AND MORE SEVERE RHEUMATOID ARTHRITIS
Nerviani, A; Mauro, D; Pagani, S; Lliso-Ribera, G; Rivellese, F; Lewis, M; Bombardieri, M; Humby, F; Pitzalis, C (2018-06) -
Rituximab versus tocilizumab and B-cell status in TNF-alpha inadequate-responder rheumatoid arthritis patients: the R4-RA RCT
Humby, F; Durez, P; Buch, MH; Lewis, MJ; Bombardieri, M; John, C; Rizvi, H; Warren, L; Peel, J; Fossati-Jimack, L (2022)<h4>Background</h4>Although biological therapies have transformed the outlook for those with rheumatoid arthritis, there is a lack of any meaningful response in approximately 40% of patients. The role of B cells in rheumatoid ... -
Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial.
Humby, F; Durez, P; Buch, MH; Lewis, MJ; Rizvi, H; Rivellese, F; Nerviani, A; Giorli, G; Mahto, A; Montecucco, C (2021-01-23)BACKGROUND: Although targeted biological treatments have transformed the outlook for patients with rheumatoid arthritis, 40% of patients show poor clinical response, which is mechanistically still unexplained. Because more ... -
Rituximab versus Tocilizumab in anti-TNF inadequate responder patients with Rheumatoid Arthritis (R4RA): a stratified, biopsy-driven, multi-centre, randomised, open label, controlled clinical trial – 16 week outcomes Article (Randomised Controlled Trial)
Pitzalis, C; Humby, F; Rivellese, F; Nerviani, A; Lewis, M -
Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial
Rivellese, F; Surace, AEA; Goldmann, K; Sciacca, E; cubuk, C; Giorli, G; John, CR; Nerviani, A; Fossati-Jimack, L; Thorborn, G (2022) -
Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials
Rivellese, F; Nerviani, A; Giorli, G; Warren, L; Jaworska, E; Bombardieri, M; Lewis, MJ; Humby, F; Pratt, AG; Filer, A (2023-11-01)Background: Despite highly effective targeted therapies for rheumatoid arthritis, about 40% of patients respond poorly, and predictive biomarkers for treatment choices are lacking. We did a biopsy-driven trial to compare ... -
SYNOVIAL MAST CELLS AND RESPONSES TO SYNTHETIC AND BIOLOGIC DMARDS IN EARLY AND ESTABLISHED RHEUMATOID ARTHRITIS
Rivellese, F; Nerviani, A; Mauro, D; Pagani, S; Humby, F; Pitzalis, C (2018-06) -
Synovial Mast Cells Associate with High Disease Activity and Predict Radiographic Progression at 12 Months in Patients with Early Rheumatoid Arthritis
Rivellese, F; Humby, F; Kelly, S; de Paulis, A; Marone, G; Pitzalis, C (2016) -
SYNOVIAL MAST CELLS CORRELATE WITH INFLAMMATION AND CELLULAR INFILTRATION AND ARE ASSOCIATED WITH ECTOPIC LYMPHOID STRUCTURES IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS
Rivellese, F; Humby, F; Kelly, S; Rocher, V; Pitzalis, C (Oxford University Press, 2016-04-24)The analysis of synovial membrane has gained much attention in recent years as a biomarker for patient stratification in RA. Different degrees of cellular infiltration have been described, leading to the definition of ... -
SYNOVIAL MAST CELLS CORRELATE WITH LOCAL AND SYSTEMIC INFLAMMATION AND ARE FUNCTIONALLY ASSOCIATED WITH ECTOPIC LYMPHOID STRUCTURES IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS
Rivellese, F; Humby, F; Kelly, S; Nerviani, A; Mauro, D; Rocher-Ros, V; El Shikh, ME; de Paulis, A; Marone, G; Pitzalis, C (2016-06)