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Grapefruit Juice and Statins (Invited Letter in Response to Bailey)
We determined the validity of current medical advice to avoid grapefruit juice consumption while taking 3 widely used statins. A daily glass of grapefruit juice increases blood levels of simvastatin and lovastatin by about ...
An overview of concepts and approaches used in estimating the burden of congenital disorders globally.
(2018-10)
Congenital disorders are an important cause of pregnancy loss, premature death and life-long disability. A range of interventions can greatly reduce their burden, but the absence of local epidemiological data on their ...
Chromosomal disorders: estimating baseline birth prevalence and pregnancy outcomes worldwide.
(2018-10)
Chromosomal disorders, of which Down syndrome is the most common, can cause multi-domain disability. In addition, compared to the general population, there is a higher frequency of death before the age of five. In many ...
Public health failure in the prevention of neural tube defects: time to abandon the tolerable upper intake level of folate.
(2018)
The neural tube defects anencephaly and spina bifida are two of the most common serious congenital malformations. Most cases can be prevented by consuming sufficient folic acid immediately before pregnancy and in early ...
EUROmediCAT signal detection: an evaluation of selected congenital anomaly-medication associations.
(2016-10)
AIMS: To evaluate congenital anomaly (CA)-medication exposure associations produced by the new EUROmediCAT signal detection system and determine which require further investigation. METHODS: Data from 15 EUROCAT registries ...
EUROmediCAT signal detection: a systematic method for identifying potential teratogenic medication.
(2016-10)
AIMS: Information about medication safety in pregnancy is inadequate. We aimed to develop a signal detection methodology to routinely identify unusual associations between medications and congenital anomalies using data ...