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    Grapefruit Juice and Statins (Invited Letter in Response to Bailey) 
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    • Grapefruit Juice and Statins (Invited Letter in Response to Bailey)
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    • Centre for Environmental and Preventive Medicine (CEPM)
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    Grapefruit Juice and Statins (Invited Letter in Response to Bailey)

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    Accepted version (17.19Kb)
    Editors
    Alpert, J
    Volume
    129
    Pagination
    26 - 29 (4)
    Publisher
    Elsevier
    Publisher URL
    http://www.amjmed.com/article/S0002-9343(15)00774-3/fulltext
    DOI
    10.1016/j.amjmed.2015.07.036.
    Journal
    American Journal of Medicine
    Issue
    1
    ISSN
    1555-7162
    Metadata
    Show full item record
    Abstract
    We determined the validity of current medical advice to avoid grapefruit juice consumption while taking 3 widely used statins. A daily glass of grapefruit juice increases blood levels of simvastatin and lovastatin by about 260% if taken at the same time (about 90% if taken 12 hours apart), and atorvastatin by about 80% (whenever taken). Simvastatin 40 mg, lovastatin 40 mg, and atorvastatin 10 mg daily reduce low-density lipoprotein (LDL) cholesterol levels in a 60-year-old man with an LDL cholesterol of 4.8 mmol/L by 37%, reducing ischemic heart disease risk by 61%. When simvastatin or lovastatin are taken at the same time as grapefruit juice, the estimated reduction in LDL cholesterol is 48%, and in heart disease is 70%. If the juice is taken 12 hours before these statins, the reductions are, respectively, 43% and 66%, and for atorvastatin, 42% and 66%. The increased rhabdomyolysis risk from grapefruit juice consumption due to the increased effective statin dose is minimal compared with the greater effect in preventing heart disease. Grapefruit juice should not be contraindicated in people taking statins.
    Authors
    Lee, JW; Morris, JK; WALD, NJ
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/15039
    Collections
    • Centre for Environmental and Preventive Medicine (CEPM) [291]
    Language
    English
    Licence information
    http://dx.doi.org/10.1016/j.amjmed.2015.07.036
    Copyright statements
    Copyright © 2016 Elsevier Inc.
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